Pathology Oncology Research

, Volume 8, Issue 2, pp 125–128 | Cite as

Down regulation of endothelial adhesion molecules in node positive breast cancer: Possible failure of host defence mechanism

  • Maya Madhavan
  • Priya Srinivas
  • Elizabeth Abraham
  • Iqbal Ahmed
  • N. R. Vijayalekshmi
  • Prabha Balaram


Endothelial cell adhesion molecules (CAMs) are important in tumorigenesis and host defense mechanism. Their status in breast cancer with regard to nodal invasion is not yet known. Hence we looked at the expression of three important CAMs: VCAM, ICAM and E-selectin. A downregulation of all these CAMs was noted in node positive breast cancer in comparison to node negative cases. This suggests shedding of these molecules in cases with nodal metastasis which might help the tumor cells to escape the host defense mechanism. On multivariate analysis, VCAM alone emerged as an independent predictor of nodal metastasis.


VCAM ICAM E-selectin invasion breast cancer 


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  1. 1.
    Nicolson GL: Organ colonization and cell-surface properties of malignant cells. Biochim Biophys Acta 695:113–176, 1982.PubMedGoogle Scholar
  2. 2.
    Pauli BU, Augustin-Voss HG, El-Sabban ME, et al: Organ preference of metastasis. The role of endothelial cell adhesion molecules. Cancer Metastasis Review 9:175–189, 1990.CrossRefGoogle Scholar
  3. 3.
    Nicolson GL: Metastatic tumor cell interaction with endothelium, basement membrane and tissue. Curr Opin Cell Biol 1:1009–1019, 1989.PubMedCrossRefGoogle Scholar
  4. 4.
    Liotta LA: Tumor invasion and metastasis of the extracellular matrix. Cancer Res 46:1–7, 1986.PubMedCrossRefGoogle Scholar
  5. 5.
    Harning R, Mainolfi E, Brystryn JC, et al: Serum levels of circulating intercellular adhesion molecule 1 in human malignant melanoma Cancer Res 51:5003–5005, 1991.PubMedGoogle Scholar
  6. 6.
    Srivastava MD, Srivastava A, Srivastava BI: Soluble interleukin 2 receptor, soluble CD8 and soluble intercellualr adhesion molecule 1 levels in hematologic malignancies Leuk Lymphoma 12:241–251, 1994.PubMedCrossRefGoogle Scholar
  7. 7.
    Koyama S, Ebihara T, Fukao K: Expression of intercellular adhesion moleculel (ICAM-1)during the development of invasion and/or metastasis of gastric carcinoma. J Cancer Res Clin Oncol 118:609–614, 1992.PubMedCrossRefGoogle Scholar
  8. 8.
    Pober JS, Cotran RS: Immunologic interactions of T lymphocytes with vascular endothelium. Adv Immunol 50:261–302, 1991.PubMedCrossRefGoogle Scholar
  9. 9.
    Stoolman LM: Adhesion molecules controlling lymphoctye migration. Cell 56:907–910, 1989.PubMedCrossRefGoogle Scholar
  10. 10.
    Osborn L: Leukocyte adhesion to endothelium in inflammation. Cell 62:3–6, 1990.PubMedCrossRefGoogle Scholar
  11. 11.
    Osborn L, Hession C, Tizard R, et al: Direct expression cloning of Vascular cell adhesion molecule-1, a cytokine induced endothelial protein that binds to lymphocytes. Cell 59:1203–1211, 1989.PubMedCrossRefGoogle Scholar
  12. 12.
    Vogetseder W, Feichtinger H, Schulz TF, et al: Expression of 7F7-antigen, a human adhesion molecule identical to Intercellular adhesion molecule-1 (ICAM-1) in human carcinomas and their stromal fibroblasts. Int J Cancer 43:768–773, 1989.PubMedCrossRefGoogle Scholar
  13. 13.
    Makgoba MW, Sanders ME, Ginther Luce GE, et al: Functional evidence that intercellular adhesion molecule (ICAM-1) is a ligand for LFA-1 dependent adhesion in T-cell mediated cytotoxicity. Eur J Immunol 18:637–640, 1988.PubMedCrossRefGoogle Scholar
  14. 14.
    Bevilacqua MP, Pober JS, Mendrick DL, et al: Identification of an inducible endothelial-leukocyte adhesion molecule. Proc Nat Acad Sci (Wash) 84:9238–9242, 1987.CrossRefGoogle Scholar
  15. 15.
    Lasky LA: Selectins: interpreters of cell specific carbohydrate information during inflammation. Science 258:964–969, 1992.PubMedCrossRefGoogle Scholar
  16. 16.
    Tsujisaki M, Imai K, Hirata H, et al: Detection of circulating intercellular adhesion molecule-1 antigen in malignant diseases. Clin Exp Immunol 85:3–8, 1991.PubMedGoogle Scholar
  17. 17.
    Viac J, Gueniche A, Faure M, et al: Soluble intercellular adhesion molecule 1(sICAM-1) and malignant melanoma. Cancer Letters 72:191–194, 1993.PubMedCrossRefGoogle Scholar
  18. 18.
    Gruss HJ, Dolken G, Brach MA, et al: Serum levels of circulating ICAM-1 are increased in Hodgkins disease. Leukemia 7:1245–1249, 1993.PubMedGoogle Scholar
  19. 19.
    Wittig BM, Treichel U, Blaheta R, et al: Soluble E-selectin enhances ICAM-1 expression in human tumor cell lines. Exp Cell Res 237:364–70, 1997.PubMedCrossRefGoogle Scholar
  20. 20.
    Lawson C, Ainsworth M, Yacoub M, et al: Ligation of ICAM-1 on endothelial cells leads to expression of VCAM-1 via a nuclear factor-KB independent mechanism. J Immunol 162:2990–6. 1999.PubMedGoogle Scholar
  21. 21.
    Rothlein R, Mainolf EA, Czajkowski M, Marlin SD: A form of circulating ICAM-1 in human serum. J Immunol 147:3788–3793, 1991.PubMedGoogle Scholar
  22. 22.
    Seth R, Raymond FD, Mukgoba MW: Cirulating ICAM-1 isoforms: diagnostic prospects for inflammatory and immune disorders. Lancet 338:83–84, 1991.PubMedCrossRefGoogle Scholar
  23. 23.
    Kageshita Y, Yoshii A, Kimura T, et al: Analysis of expression and soluble form of intercellular adhesion molecule-1 in malignant melanoma. J Dermatol 19:836–840, 1992.PubMedGoogle Scholar
  24. 24.
    Anastossiou G, Schilling H, Stang A, et al: Expression of the cell adhesion molecules ICAM-1, VCAM-1 and NCAM in uveal melanoma: A clinicopathological study. Oncology 58:83–88, 2000.CrossRefGoogle Scholar
  25. 25.
    Pizzolo G, Vinante F, Nadali G, et al: ICAM-1 tissue overexpression associated with increased serum levels of its soluble form in Hodgkins disease. Br J Haematol 84:161–162, 1993.PubMedCrossRefGoogle Scholar
  26. 26.
    Vogetseder W, Feichtinger H, Schulz TF, et al: Expression of 7F7 antigen, a human adhesion molecule identical to intercellular adhesion molecule-1 (ICAM-1) in human carcinomas and their stromal fibroblasts. Int J Cancer 43:768–773, 1989.PubMedCrossRefGoogle Scholar
  27. 27.
    Gearing AJH, Newman W: Circulating adhesion molecules in disease. Immunol Today 14:506–512, 1993.PubMedCrossRefGoogle Scholar
  28. 28.
    Banks RE, Gearing AJH, Hemingway IK, et al: Circulating intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in human malignancies. Br J Cancer 68:122–124, 1993.PubMedGoogle Scholar
  29. 29.
    Liu CM, Sheen TS, Ko JY, et al: Circulating intercellular adhesionmolecule 1 (ICAM-1), E-selectin and vascular cell adhesion molecule 1 (VCAM-1) in head and neck cancer. Br J Cancer 79:360–362, 1999.PubMedCrossRefGoogle Scholar

Copyright information

© Arányi Lajos Foundation 2002

Authors and Affiliations

  • Maya Madhavan
    • 1
  • Priya Srinivas
  • Elizabeth Abraham
    • 2
  • Iqbal Ahmed
    • 3
  • N. R. Vijayalekshmi
    • 4
  • Prabha Balaram
    • 1
  1. 1.Research DivisionRegional Cancer CentreTrivandrum, KeralaIndia
  2. 2.Division of HistopathologyRegional Cancer CentreTrivandrum, Kerala
  3. 3.Division of Surgical OncologyRegional Cancer CentreTrivandrum, Kerala
  4. 4.Department of BiochemistryUniversity of KeralaTrivandrum, KeralaIndia

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