Neurotoxicity Research

, Volume 11, Issue 3–4, pp 183–202

Neurotoxicity of substituted amphetamines: Molecular and cellular mechanisms

  • Jean Lud Cadet
  • Irina N. Krasnova
  • Subramaniam Jayanthi
  • Johnalyn Lyles
Article

Abstract

The amphetamines, including amphetamine (AMPH), methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA), are among abused drugs in the US and throughout the world. Their abuse is associated with severe neurologic and psychiatric adverse events including the development of psychotic states. These neuropsychiatric complications might, in part, be related to drug-induced neurotoxic effects, which include damage to dopaminergic and serotonergic terminals, neuronal apoptosis, as well as activated astroglial and microglial cells in the brain. The purpose of the present review is to summarize the toxic effects of AMPH, METH and MDMA. The paper also presents some of the factors that are thought to underlie this toxicity. These include oxidative stress, hyperthermia, excitotoxicity and various apoptotic pathways. Better understanding of the cellular and molecular mechanisms involved in their toxicity should help to generate modern therapeutic approaches to prevent or attenuate the long-term consequences of amphetamine use disorders in humans.

Keywords

Substituted amphetamines Methamphetamine Methylenedioxyamphetamine MDMA Serotoninergic neurons Dopaminergic neurons Hyperthermia Neurotoxicity 

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Copyright information

© Springer 2007

Authors and Affiliations

  • Jean Lud Cadet
    • 1
  • Irina N. Krasnova
    • 1
  • Subramaniam Jayanthi
    • 1
  • Johnalyn Lyles
    • 1
  1. 1.Molecular Neuropsychiatry Branch, DHHS/NIH/NIDAIntramural Research ProgramBaltimoreUSA

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