Neurotoxicity Research

, Volume 11, Issue 1, pp 61–71

From dopaminergic genes to psychiatric disorders

  • Janet Hoenicka
  • María aragüés
  • Guillermo Ponce
  • Roberto Rodríguez-Jiménez
  • Miguel A. Jiménez-Arriero
  • Tomás Palomo
Article

DOI: 10.1007/BF03033483

Cite this article as:
Hoenicka, J., aragüés, M., Ponce, G. et al. neurotox res (2007) 11: 61. doi:10.1007/BF03033483

Abstract

Individual vulnerability to develop neurological and psychiatric disorders is associated with both genetic and environmental factors. Association studies in patients have explored the contribution of gene variants in the dopaminergic system in these disorders. This system is involved in motor control, endocrinological function, the reward system and cognition. The diverse physiological functions of dopamine are mediated by five different dopamine receptors, encoded by the genesDRD1, DRD2, DRD3, DRD4 andDRD5. These genes have various types of polymorphisms that can produce changes in the genetic product or expression levels. In recent years, the development of new technologies for genetic analysis, and a wider comprehension of the genetic sequences of these genes have increased our understanding of the implications of the dopaminergic system in both health and pathological states. It has also allowed the identification of genetic variants that may represent risk or protection factors for a variety of psychiatric disorders.

Keywords

Dopamine Dopamine genes Psychiatric disorders DRD1 DRD2 DRD3 DRD4 DRD5 Genes Genetic analysis Environment Reward Cognition ADHD Attention deficit hyperactivity disorder Schizophrenia Bipolar disorder Drug abuse 

Copyright information

© Springer 2007

Authors and Affiliations

  • Janet Hoenicka
    • 1
    • 2
    • 3
  • María aragüés
    • 1
    • 2
    • 3
  • Guillermo Ponce
    • 1
    • 2
    • 3
  • Roberto Rodríguez-Jiménez
    • 1
    • 2
    • 3
  • Miguel A. Jiménez-Arriero
    • 1
    • 2
    • 3
  • Tomás Palomo
    • 1
    • 2
    • 3
  1. 1.Servicio de PsiquiatríaHospital Universitario 12 de OctubreMadridSpain
  2. 2.Departamento de Bioquímica, Facultad de MedicinaUniversidad Complutense de MadridMadridSpain
  3. 3.Hospital Gregorio MarañónServicios de Salud MentalMadridSpain

Personalised recommendations