Neurotoxicity Research

, Volume 5, Issue 1–2, pp 45–51

Neurodevelopmental liabilities in epilepsy



The epilepsies are a heterogenous group of cortical disorders characterized by recurrent excessive neuronal activity. In the pathophysiology of these disorders are included mechanisms of abnormal neuronal potential generation secondary to channelopathies, excitoxic mechanisms secondary to imbalance in neuronal excitation and inhibition, and abnormalities of neuronal organization. In this article the mechanisms of the epilepsies are reviewed, in the setting of three examples: autosomal dominant nocturnal frontal lobe epilepsy, mesial temporal sclerosis and malformations of cortical development.


Epilepsy Channelopathies Mesial temporal sclerosis Malformation of cortical development 


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Copyright information

© Springer 2003

Authors and Affiliations

  1. 1.Programa de EpilepsiaServicio de Neurología, Hospital Ruber InternacionalMadridSpain

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