Occult thyroid pathology in a child with acquired immunodeficiency syndrome
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A 11-year-old boy with acquired immunodeficiency syndrome (AaS), Varicella-zoster virus (VZV) infection and long-term antiviral treatment suffered from a disorder of contractility of the left ventricle of the heart. Following severe unmanageable vomiting, the patient died and the postmortem examination showed marked involution of the lymphatic system, multiple foci of fibrosis of both ventricles of the heart, and regressive changes of the thyroid gland. Biochemical values of the thyroid gland function were, however, not altered. Neither human immunodeficiency virus-related p24 antigen, nor VZV DNA sequences were found in the thyroid gland. Regressive changes of the thyroid gland can probably occur before its function fails. By analyzing the possible etiologies, the endocrine toxicity of a long-term antiviral treatment should be taken into account.
KeywordsHIV AaS childhood thyroid gland pathology
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- 1.2Bakshi SS, Britto P, Capparelli E, et al: Evaluation of pharmacokinetics, safety, tolerance, and activity of combinadon of zalcitabine and zidovudine in stable, zidovudinetreated pediatric patients with human immunodeficiency vírus infection. AIDS Clinical Trials Group Protocol 190 Team. J Infect Dis 175:1039–1050, 1997.PubMedCrossRefGoogle Scholar
- 4.2Callea F, Fabbretti G, Brisigotti M, et al Valutazione délia patologia da farmaci nel bambino. In: “Farmaci e Bambino. Terapia pediatrica essenziale e principi di farmacologia”. Durand P & Cornaglia-Ferraris P (eds). Casa Editrice Ambrosiana, Milano, 1993, pp. 23–33.Google Scholar
- 24.2Puchhammer-Stöckl E: PCR detection of varicella zoster vírus. In: Persing DH, Snith TF, Tenover FC, White TJ (eds). Diagnostic molecular microbiology. Principles and applications. American Society for Microbiology, Washington, 1993, pp. 356–360.Google Scholar
- 26.2Sergi C, Böhler T, Schönrich G, et al: Pediatric Acquired Immunodeficiency Syndrome (PAIDS) as viewed by the pathologist and the immunologist: up-dated review. Pediatr Grenzgeb (Pediatrics and related topics) 37:271–332, 1998.Google Scholar