A study of methoxyflurane anaesthesia

  • R. A. Millar
  • M. E. Morris


Methoxyflurane anaesthesia in dogs produced respiratory depression, a gradual moderate decline in blood pressure with minimal changes in heart rate, and no significant effect on blood glucose or plasria adrenaline and noradrenaline levels. Hypercarbia induced an immediate hypotensive response-and caused sigruficant increases in both catecholamines; haemorrhage was followed by significant increases in plasma adrenaline. Blood glucose increased as a result of hypercarbia and haemorrhage during methoxyfluran0e anaesthesia.


Halothane Methoxyflurane Flurane Cent Carbon Dioxide Plasma Catecholamine Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


L’anesthésie au méthoxyflurane, chez Ies chiens, s’accompagne d’une dépression respiratoire, d’une chute modérée graduielle de la tension artérielle avec des changements minimes du rythme cardiaque mais elle demeure sans effet important sur le taux de glucose sanguin, pas plus que sur le taux d’adrénaline et de nora-drenaline plasmatiques. L’hypercarbie a entraîné une hypotension immédiate et a produit une augmentation importante des catechoJamines; 1’hémorragie a entraîné une augmentation importante du taux d’adrénaline plasmatique. Au cours de léanesthésie au méthoxyflurane, à cause de léhypercarbie et de 1’hémorragie, le taux deglucose sanguin a augmenté.


  1. 1.
    Artusio, J. F., Poznak, A.;Hunt, R. E.;Tiers, F. M.; &Alexander, M. Methoxyflurane in Man. Anesthesiology21: 512 (1960).PubMedCrossRefGoogle Scholar
  2. 2.
    Poznak, A., Ray, B. S., &Artusio, J. F., Jr. Methoxyflurane as an Anesthetic for Neurological Surgery. J. Neurosurg.17: 477 (1960).PubMedCrossRefGoogle Scholar
  3. 3.
    Millar, R. A., Keener, E. B., &BeVfey, B. G. Plasma Adrenaline and Noradlrenaline After Phenoxybenzamine, and during Haemorrhagic Hypotension in Normal and Adrenal- ectomized Dogs. Brit. J. Pharmacol.14: 9 (1959).PubMedGoogle Scholar
  4. 4.
    Somogyi, M. Determination of Blood Sugar. J. Biol. Chejin.160: 69 (1945).Google Scholar
  5. 5.
    Somogyi, M. Notes on Sugar Determination. J.Biol. Chem.196: 19 (1952).Google Scholar
  6. 6.
    Astrup, P. A Simple Electrometric Technique for the Determination of Carbon Dioxide Tension in Blood and Plasma, Total Content of Carbon Eioxide in Plasma, and Bicarbonate Content in “Separated” Plasma at a Fixed Carbon Dioxide Tension (40 mm. Hg). Scand. J. Clin. Lab. Invest.8: 33 (1956).PubMedCrossRefGoogle Scholar
  7. 7.
    Millar, R. A., &Morris, M. E. Induced Sympathetic Stimulation during Halothane Anaesthesia. Canad. Anaesth. Soc. J.7: 423 (1960).PubMedCrossRefGoogle Scholar
  8. 8.
    Millar, R. A., &Morris, M. E. To be published.Google Scholar
  9. 9.
    Wasmuth, C. E.;Grieg, J. H.;Homi, J.;Moraca, P.;NiyIzi, H.;Bitte, E. M.; &Hale, D. Methoxyfiurane-A New Anesthetic Agent: A Clinical Evaluation Based onI 206 Cases. Cleveland Clinic Quarterly27: 174 (1960).PubMedGoogle Scholar

Copyright information

© Canadian Anesthesiologists 1961

Authors and Affiliations

  • R. A. Millar
    • 1
  • M. E. Morris
    • 1
  1. 1.Department of AnaesthesiaMontreal Neurological Institute & McGill UniversityMontreal

Personalised recommendations