Download PDF

Canadian Journal of Anaesthesia

, Volume 44, Supplement 1, pp R3–R12 | Cite as

New induction agents

  • J. W. Sear
Referesher Course Outline Track I
  • 196 Downloads

Keywords

Thiopentone Etomidate Racemate Induction Agent Methohexitone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Les nouveaux agents d’induction

Download to read the full article text

References

  1. 1.
    Westrin P, Jonmarker C, Werner O. Dissolving methohexital in a lipid emulsion reduces pain associated with intravenous injection. Anesthesiology 1992; 76: 930–4.PubMedCrossRefGoogle Scholar
  2. 2.
    Doenicke A, Roizen MF, Nebauer AB, Kugler A, Hoernecke R, Beger-Hintzen H. A comparison of two formulations of etomidate, 2-hydroxypropyl-βcyclodextrin (HPCD) and propylene glycol. Anesth Analg 1994; 79: 933–9.PubMedCrossRefGoogle Scholar
  3. 3.
    Habazettl H, Vollmar B, Röhrich F, Conzen P, Doenicke A, Baethmann A. Anaesthetic potency of a liposomal propanidid preparation. Experimental studies in rats. (German) Anaesthesist 1992; 41: 448–56.PubMedGoogle Scholar
  4. 4.
    Klockgether-Radke A, Kersten J, Schröder T, Stafforst D, Kettler D, Hellige G. Anästhesie mit propanidid in liposomaler Zubereitung. Eine experimentelle Studie am schwein. Anaesthesist 1995; 44: 573–80.PubMedCrossRefGoogle Scholar
  5. 5.
    Doenicke AW, Roizen MF, Rau J, Kellermann W, Bubi J. Reducing pain during propofol injection: the role of the solvent. Anesth Analg 1996; 82: 472–6.PubMedCrossRefGoogle Scholar
  6. 6.
    Doenicke A, Roizen MF, Rau J, Kugler J. Two different solvents for propofol: is hypnotic effect different? Anesth Analg 1996; 82: S94.CrossRefGoogle Scholar
  7. 7.
    Bulen SJ, Lysko GS, Gough WB. The effect of a cydodextrin vehicle on the cardiovascular profile of propofol in rats. Anesth Analg 1996; 82: 920–4.CrossRefGoogle Scholar
  8. 8.
    White PF, Schüttler J, Shafer A, Stanski DR, Horai Y, Trevor AJ. Comparative pharmacology of the ketamine isomers. Br J Anaesth 1985; 57: 197–203.PubMedCrossRefGoogle Scholar
  9. 9.
    White PF, Ham J, Way WL, Trevor AJ. Pharmacology of ketamine isomers in surgical patients. Anesthesiology 1980; 52: 231–9.PubMedCrossRefGoogle Scholar
  10. 10.
    Schüttler J, Stanski DR, White PF, et al. Pharmacodynamic modeling of the EEG effects of ketamine and its enantiomers in man. J Pharmacokinet Biopharm 1987; 15: 241–53.PubMedCrossRefGoogle Scholar
  11. 11.
    Geisslinger G, Hering W, Thomann P, Knoll R, Kamp H-D, Brune K. Pharmacokinetics and pharmacodynamics of ketamine enantiomers in surgical patients using a stereoselective analytical method. Br J Anaesth 1993; 70: 666–71.PubMedCrossRefGoogle Scholar
  12. 12.
    Kharasch ED, Labroo R. Metabolism of ketamine stereoisomers by human liver microsomes. Anesthesiology 1992; 77: 1201–7.PubMedCrossRefGoogle Scholar
  13. 13.
    Graf BM, Vicenzi MN, Martin E, Bosnjak ZJ, Stowe DF. Ketamine has stereospecific effects in the isolated perfused guinea pig heart. Anesthesiology 1995; 82: 1426–37.PubMedCrossRefGoogle Scholar
  14. 14.
    Sekino N, Endou M, Hajiri E, Okumura F. Nonstereospecific actions of ketamine isomers on the force of contraction, spontaneous beating rate, and Ca2+ current in the guinea pig heart. Anesth Analg 1996; 83: 75–80.PubMedCrossRefGoogle Scholar
  15. 15.
    Norberg L, Wahlström G, Bäckström T. The anaesthetic potency of 3α-hydroxy-5α-pregnan-20-one and 3αhydroxy-5β-pregnan-20-one determined with an intravenous EEG-threshold method in male rats. Pharmacol Toxicol 1987; 61: 42–7.PubMedCrossRefGoogle Scholar
  16. 16.
    Schüttler J, Hering W, Ihmsen H, Geisslinger G, Rügheimer E. Pharmacokinetic/-dynamic modeling of the new intravenous anesthetic eltanolone. Anesthesiology 1994; 81: A409.CrossRefGoogle Scholar
  17. 17.
    Sear JW, Jewkes C, Wanigasekera V. Hemodynamic effects during induction, laryngoscopy, and intubation with eltanolone (5β-pregnanolone) or propofol. A study in ASA I and II patients. J Clin Anesth 1995; 7: 126–31.PubMedCrossRefGoogle Scholar
  18. 18.
    Tassant P, Jänicke U, Ott E, Groh J, Conzen P. Hemodynamic effects of anesthetic induction with eltanolone-fentanyl versus thiopental-fentanyl in coronary artery bypass patients. Anesth Analg 1995; 81: 469–73.CrossRefGoogle Scholar
  19. 19.
    Spens HJ, Drummond GB, Wraith PK. Changes in chest wall compartment volumes on induction of anaesthesia with eltanolone, propofol and thiopentone. Br J Anaesth 1996; 76: 369–73.PubMedGoogle Scholar
  20. 20.
    Figdor SK, Kodet MJ, Bloom BM, Agnello EJ, P’An SY, Laubach GD. Central activity and structure in a series of water-soluble steroids. J Pharmacol Exp Ther 1957; 119: 299–309.PubMedGoogle Scholar
  21. 21.
    Gemmell DK, Campbell AC, Anderson A, Byford A, Hill-Venning C, Marshall RJ. ORG 20599: a new water soluble aminosteroid intravenous anaesthetic. Br J Pharmacol 1994: 111(Suppl): 189P.Google Scholar
  22. 22.
    Gemmell DK, Byford A, Anderson A, et al. The anaesthetic and GABA modulatory actions of ORG 21465, a novel water soluble steroidal intravenous anaesthetic agent. Br J Pharmacol 1995; 116(Suppl): 443P.Google Scholar
  23. 23.
    Ihmsen H, Hering W, Albrecht S, et al. Pharmacokinetics of the new benzodiazepines RO 48-6791 and RO 48-8684 in comparison with midazolam in young and elderly volunteers. Anesthesiology 1996; 85: A317.Google Scholar
  24. 24.
    White M, Kenny GNC. Intravenous propofol anaesthesia using a computerised infusion system. Anaesthesia 1990; 45: 204–9.PubMedCrossRefGoogle Scholar
  25. 25.
    Sear JW, Glen JB. Propofol administered by a manual infusion regimen. Br J Anaesth 1995; 74: 362–7.PubMedCrossRefGoogle Scholar

Copyright information

© Canadian Anesthesiologists 1997

Authors and Affiliations

  • J. W. Sear
    • 1
  1. 1.Nuffield Department of AnaestheticsUniversity of Oxford, John Radcliffe HospitalHeadington

Personalised recommendations