• Akinori Yamazaki
  • Hiroyuki KinoshitaEmail author
  • Manabu Shimogai
  • Keisuke Fujii
  • Katsutoshi Nakahata
  • Yasuo Hironaka
  • Hiroshi Iranami
  • Yoshio Hatano
General Anesthesia at]Landiolol attenuates tachycardia in response to endotracheal intubation without affecting blood pressure



Beta-adrenergic receptor antagonists (ß-antagonists) have long been used to control perioperative tachyarrhythmias. The effects of a ß1-antagonist, landiolol, on perioperative hemodynamics are unknown. We aimed to determine the appropriate dosage of landiolol for the treatment of hemodynamic changes in response to endotracheal intubation.


Sixty-four patients without heart disease or hypertension, were assigned to receive saline (group C) or landiolol (0.1 or 0.3 mg kg-1; groups L1 andL3). Anesthesia was induced with propofol (2 mg kg-1 iv) followed by saline or landiololiv. After ventilation with facemask using 2% sevoflurane in 100% oxygen for 90 sec, endotracheal intubation was performed. After intubation, anesthesia was maintained using 1 % sevoflurane in combination with 50% nitrous oxide. Values of heart rate and mean arterial blood pressure were recorded before induction to five minutes after intubation.


In group C, heart rate and mean blood pressure increased simultaneously after tracheal intubation, compared with baseline values. Heart rate values were attenuated immediately before as well as after intubation in groupL3, compared with groups C and L1. Heart rate did not increase after tracheal intubation in group L1, compared with baseline. In contrast, mean arterial blood pressure values did not differ among groups.


The newly developed ß1-antagonist landiolol (0.1 and 0.3 mg·kg-1) may help prevent tachycardia without affecting blood pressure during the induction of anesthesia.


Sevoflurane Arterial Blood Pressure Tracheal Intubation Endotracheal Intubation Esmolol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Le landiolol diminue la tachycardie en réponse à l’intubation endotrachéale sans affecter la tension artérielle



Les antagonistes des récepteurs bêta-adrénergiques (ßantagonistes) ont été longtemps utilisés pour contrôler les tachyarythmies périopératoires. Les effets d’un ß 1-antagoniste, le landiolol, sur ïhémodynamique périopératoire sont inconnus. Nous voulions déterminer le dosage approprié de landiolol pour traiter les changements hémodynamiques provoqués par l’intubation endotrachéale.


Soixante-quatre patients sans cardiopathie, ni hypertension, ont reçu une solution saline (group C) ou du landiolol (0,1 ou 0,3 mg·kg-1; groupes L1 et L3). L’anesthésie a été induite avec du propofol (2 mg·kg-1 iv) suivi de la solution saline ou du landiolol iv. Après ventilation au masque, avec du sévoflurane à 2 % dans de l’oxygène à 100 pendant 90 s, l’intubation endotrachéale a été réalisée. Puis, l’anesthésie a été maintenue avec du sévoflurane à 1 % combiné à du protoxyde d’azote à 50 %. La fréquence cardiaque et la tension artérielle moyenne ont été enregistrées avant l’induction et jusqu’à cinq minutes après l’intubation.


Dans le groupe C, la fréquence cardiaque et la tension artérielle moyenne ont augmenté simultanément après l’intubation endotrachéale, par rapport aux valeurs de base. La fréquence cardiaque a baissé immédiatement avant et après l’intubation dans le groupe L3 comparé aux groupes C et L1. La fréquence cardiaque n’a pas augmenté, sur les mesures de base, après l’intubation endotrachéale dans le groupe L1. Les valeurs de la tension artérielle moyenne étaient comparables entre les groupes. as]Conclusion p ]Le nouveau ß 1-antagoniste landiolol (0,1 et 0,3 mg·kg-1) peut aider à prévenir la tachycardie sans affecter la tension artérielle pendant l’induction de l’anesthésie.


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Copyright information

© Canadian Anesthesiologists 2005

Authors and Affiliations

  • Akinori Yamazaki
    • 1
  • Hiroyuki Kinoshita
    • 1
    Email author
  • Manabu Shimogai
    • 1
  • Keisuke Fujii
    • 1
  • Katsutoshi Nakahata
    • 1
  • Yasuo Hironaka
    • 1
  • Hiroshi Iranami
    • 1
  • Yoshio Hatano
    • 2
  1. 1.Department of AnesthesiaJapanese Red Cross Society Wakayama Medical CenterJapan
  2. 2.Department of AnesthesiologyWakayama Medical UniversityWakayamaJapan

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