Canadian Journal of Anaesthesia

, Volume 43, Issue 1, pp 35–38 | Cite as

RETRACTED ARTICLE: Granisetron reduces vomiting after strabismus surgery and tonsillectomy in children

  • Yoshitaka Fujii
  • Hiroyoshi Tanaka
  • Hidenori Toyooka
Reports of Investigation

Abstract

Purpose

To evaluate the antiemetic efficacy of granisetron, a selective 5-hydroxytryptamine type 3 receptor antagonist, on postoperative vomiting in children undergoing general anaesthesia for strabismus repair and tonsillectomy with or without adenoidectomy.

Methods

In a randomized, placebo-controlled, double-blind study, fifty patients, 4–10 yr of age, were given a single dose of either placebo (saline, n = 25) or granisetron (40 μg · kg−1, n = 25) iv over 2–5 min after the induction of anaesthesia and prior to the surgical procedure. Postoperatively, during the first 24 hr after anaesthesia, the frequencies of retching and vomiting were recorded.

Results

There were no differences between the two groups with regard to patient characteristics, surgical procedures and anaesthetic or postoperative management. The incidence of retching was 36% and 12% after administration of placebo or granisetron, respectively (P < 0.05); the corresponding frequencies of vomiting were 32% and 8% (P < 0.05). Four children who had received placebo required another rescue antiemetic drug, whereas none who had received granisetron needed this agent.

Conclusion

Granisetron is effective in the prevention of retching and vomiting after strabismus repair and tonsillectomy in paediatric patients.

Key Words

anaesthesia: paediatric complications: vomiting vomiting: antiemetics, granisetron surgery: strabismus repair, tonsillectomy 

Résumé

Objectif

Evaluer l’efficacité antiémétique du granisetron, un antagoniste sélectif type 3 de la 5-hydroxytryptamine sur les vomissements postopératoires chez des enfants soumis à une chirurgie pour correction de strabisme et amygdalectomie avec ou sans adénoïdectomie.

Méthode

Au cours d’une étude randomisée, en double aveugle et avec placebo, 50 patients âgés de 4–10 ans, reçoivent une seule dose de placebo (soluté physiologique = 25) ou du granisetron (40 μg · kg−1, n = 25), iv en 2–5 min après l’induction de l’anesthésie et avant l’intervention. Pendant les 24 h qui suivent l’anesthésie, on enregistre la fréquence des nausées et de vomissements.

Résultats

Les deux groupes sont comparables au regard des caractéristiques individuelles, des interventions chirurgicales et de la gestion anesthésique et postopératoire. L’incidence de nausées est respectivement de 36% et de 12% après l’administration du placebo et du granisetron (P < 0,05): la fréquence correspondante des vomissements est de 32% et de 8% (P < 0,05). Quatre enfants prétraités au placebo ont besoin d’un antiémétique de sauvetage, alors qu’aucun des prétraités au granisetron n ’en a besoin.

Conclusion

Le granisetron est efficace pour prévenir les nausées et le vomissements après correction de strabisme et amygdalectomie chez les enfants.

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Copyright information

© Canadian Anesthesiologists 1996

Authors and Affiliations

  • Yoshitaka Fujii
    • 1
  • Hiroyoshi Tanaka
    • 2
  • Hidenori Toyooka
    • 1
  1. 1.Department of Anaesthesiology and Critical Care MedicineTokyo Medical and Dental University School of MedicineTokyoJapan
  2. 2.Department of AnacsthesiologyToride Kyodo General HospitalIbarakiJapan

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