RETRACTED ARTICLE: Prophylactic antiemetic efficacy of granisetron in patients with and without previous postoperative emesis

  • Yoshitaka Fujii
  • Hiroyoshi Tanaka
  • Hidenori Toyooka
Reports of Investigation

Abstract

Purpose

To evaluate the efficacy of granisetron, a selective antagonist of 5-hydroxytryptamine type 3 receptors. in the prevention of PONV in patients with and without previous postoperative emesis undergoing general anaesthesia for major gynaecological surgery.

Methods

In a randomized, double-blind, placebo-controlled trial of 90 women with (n=40) and without (n = 50) a history of PONV the patients received either granisetron (40 μg·kg−1) or placebo (saline)iv immediately before induction of anaesthesia. The same standard general anaesthetic technique, which consisted of isoflurane in nitrous oxide and oxygen and avoided opioids, was used. Nausea, vomiting and safety assessments were performed during the first 24 hr after anaesthesia.

Results

The incidence of PONV was 70% and 25% after administration of placebo and granisetron in patients with previous PONV (P < 0.05), and was 40% and 8% in patients without it, respectively (P < 0.05). The incidence of adverse events postoperatively were not different among the treatment groups.

Conclusion

Granisetron 40 μg·kg given prior to anaesthesia reduces the incidence of PONV in patients with a history of PONV as well as in patients without it.

Résumé

Objectif

Évaluer l’efficacité du granisetron, un antagoniste sélectif des récepteurs de type 3 de la 5-hydroxytryptamine. administré pour prévenir les nausées et les vomissements postopératoires (NVPO) à des patientes auparavant exemptes ou ayant souffert de cette complication et soumises à un anesthésie générale pour une intervention gynécologique majeure.

Méthodes

Étude aléatoire, à double insu, contrôlée avec placebo. Quatre-vingt-dix femmes sans (n = 40) ou avec une histoire antérieure (n = 40) de NVPO recevaient du granisetron (40 μg·kg−1) ou un placeboiv immédiatement avant l’induction de l’anesthésie. La même technique standard d’anesthésie comprenant de l’isoflurane, du protoxyde d’azote en oxygène sans morphmique. Les évaluations des nausées, des vomissements et des conditions de sécurité étaient réalisées pendant les 24 h suivant l’anesthésie.

Résultats

L’incidence des NVPO était respectivement de 70% et de 25% après l’administration du placebo et du granisetron chez les patientes ayant souffert de NVPO et de 40% et de 8% chez les patientes exemptes (P < 0,05). L’incidence de complications était la même pour les deux groupes.

Conclusion

Le gramsetron 40 μg·kg−1 administré avant une anesthésie à des patientes auparavant exemptes et ayant souffert de NVPO réduit l’incidence de cette complication.

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Copyright information

© Canadian Anesthesiologists 1997

Authors and Affiliations

  • Yoshitaka Fujii
    • 1
  • Hiroyoshi Tanaka
    • 1
  • Hidenori Toyooka
    • 2
    • 1
  1. 1.Department of AnaesthesiologyToride Kyodo General HospitalIbarakiJapan
  2. 2.Department of AnaesthesiologyUniversity of Tsukuba Institute of Clinical MedicineIbarakiJapan

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