Canadian Journal of Anaesthesia

, Volume 43, Issue 12, pp 1229–1232 | Cite as

RETRACTED ARTICLE: Granisetron and dexamethasone provide more improved prevention of postoperative emesis than granisetron alone in children

  • Yoshitaka Fujii
  • Hiroyoshi Tanaka
  • Hidenori Toyooka
Reports of Investigation



Dexamethasone decreases chemotherapy-induced emesis when added to antiemetic regimens. This study was designed to compare the effectiveness of granisetron and dexamethasone with granisetron alone in the prevention of postoperative vomiting after strabismus repair, tonsillectomy with or without adenoidectomy in children.


In a randomized, double-blind study, 60 healthy children, 4–10 yr of age, received either granisetron 40 μg · kg−1 and saline (Group S) or granisetron 40 μg · kg−1 and dexamethasone 4 mg (Group D) iv immediately after the induction of anaesthesia. All subjects received anaesthetics consisting of sevoflurane and nitrous oxide in oxygen. Postoperative pain was treated with acetaminophen pr or pentazocine iv. Postoperatively, during the first 24 hr after anaesthesia, the frequencies of retching and vomiting, and the incidence of adverse events were recorded by nursing staff.


There were no differences between the treatment groups with regard to demographics, surgical procedure, anaesthetic administered or analgesics used for postoperative pain. The frequency of the symptoms was 27% and 7% in Groups S and D, respectively (P < 0.05). The incidence of adverse events was comparable in the two groups.


The prophylactic administration of granisetron and dexamethasone was more effective than granisetron alone in the prevention of postoperative vomiting in paediatric subjects undergoing strabismus repair, tonsillectomy and adenoidectomy.

Key words

anaesthesia: paediatric complications: vomiting vomiting: antiemetics, granisetron, dexamethasone surgery: strabismus repair, tonsillectomy, adenoidectomy 



La dexaméthasone diminue les vomissements provoqués par ta chimiothérapie lorsqu’on l’associe aux médications antiémétiques. Cette étude visait à comparer l’efficacité de l’association dexaméthasone-granisetron et du granisetron seul administrés pour la prévention des vomissements postopératoires consécutifs à la correction de strabisme et à l’amygdalectomie avec ou sans adénoïdectomie chez l’enfant.


L’étude était aléatoire et en double aveugle. Elle groupait 60 enfants âgés de 4 à 10 ans qui avaient reçu soit granisetron 40 μg · kg−1 avec du sol. phys. (groupe S) ou granisetron 40 μg · kg−1 avec dexaméthasone 4 mg (groupe D) iv immédiatement après l’induction de l’anesthésie. Tous les sujets étaient anesthésiés au sévoflurane-protoxyde d’azote en oxygène. Après l’opération, pendant les premières 24 heures qui suivaient l’anesthésie, la fréquence des efforts pour vomir et les vomissements et l’incidence des effets indésirables étaient enregistrés par le personnel infirmier.


Les groupes étaient identiques au regard de la démographie, de l’intervention chirurgicale, de l’anesthésie et de l’analgésie administrée pour la douleur postopératoire. La fréquence des symptômes était de 27% dans le groupe S, et de 7% dans le groupe D (P < 0,05). L’incidence des effets indésirables était comparable entre les deux groupes.


L’administration prophylactique de granisetron et de dexaméthasone était plus efficace que le granisetron seul pour prévenir les vomissements postopératoires chez des enfants soumis à une correction de strabisme, à une amygdalectomie et à une adénoïdectomie.


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Copyright information

© Canadian Anesthesiologists 1996

Authors and Affiliations

  • Yoshitaka Fujii
    • 1
  • Hiroyoshi Tanaka
    • 1
    • 2
  • Hidenori Toyooka
    • 1
    • 3
  1. 1.Department of Anaesthesiology and Critical Care MedicineTokyo Medical and Dental University School of MedicineTokyoJapan
  2. 2.Department of AnaesthesiologyToride Kyodo General HospitalIbarakiJapan
  3. 3.Department of AnaesthesiologyTsukuba University Institute of Clinical MedicineIbarakiJapan

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