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Canadian Journal of Anesthesia

, Volume 46, Issue 11, pp 1043–1047 | Cite as

Oral clonidine reduces the requirement of prostaglandin El for induced hypotension

  • Kazuhiro Murakami
  • Tadanori Mammoto
  • Takashi Kita
  • Yuichirou Imai
  • Takashi Mashimo
  • Tadaaki Kirita
  • Masahito Sugimura
  • Yoshihiko Kishi
Reports of Investigation
Accepted:

Abstract

Purpose

To determine the effects of preanesthetic oral clonidine on the dose of prostaglandin E1 (PGE1) required to produce hypotension during anesthesia.

Method

Oral placebo, 75 μg or 150 μg clonidine were administered 60 min prior to induction of anesthesia. Anesthesia was maintained with O2: N2O (30:70) and isoflurane 1.0 %. After hemodynamic stabilization, an infusion of prostaglandin E1 was started (0.05 μg · kg−1· min−1) and the rate of infusion was adjusted to maintain mean arterial pressure (MAP) between 60–70 mmHg during operation.

Results

Duration of hypotension in placebo, 75 μg and 150μg preanesthetic oral clonidine treated groups were 132 ± 46, 117 ± 37 and 129 ± 56 min, respectively. The PGE 1 requirement in each group were 1563 ± 180 (28.6 ± 3.2), 594 ± 197 (10.8 ± 3.6) and 283 ± 30 (5.5 ± 3.6) μg (μg · kg−1), respectively. In addition, blood loss in each group were 1461 ± 389, 805 ± 240 and 931 ± 40 ml, respectively.

Conclusion

Preanesthetic oral clonidine decreased the dose of PGE 1 required to produce hypotension, and decreased the blood loss during operation.

Keywords

PGE1 Clonidine Mean Arterial Pressure Dexmedetomidine Radical Hysterectomy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Résumé

Objectif

Déterminer les effets de l’administration préanesthésique de clonidine orale sur la dose de prostaglandine E1 (PGE 1) nécessaire à la production d’hypotension pendant l’anesthésie.

Méthode

Un placebo oral, 75 μg ou 150 μg de clonidine ont été administrés 60 min avant l’induction de l’anesthésie. Lanesthésie a été maintenue avec un mélange O2: N2O (30:70) et de l’isoflurane à 1,0 %. Après la stabilisation des paramètres hémodynamiques, on a commencé la perfusion de prostaglandine E1 (0,05 μg · kg−1 · min−1) et le débit de la perfusion a été ajusté pour conserver la tension artérielle moyenne (TAM) entre 60–70 mmHg pendant l’intervention.

Résultats

La durée de l’hypotension avec le placebo ou 75 μg ou 150μg de clonidine préanesthésique orale a été de 132 ± 46, 117 ± 37 et de 129 ± 56 min, respectivement. Les besoins de PGE 1 dans chaque groupe ont été de 1563 ± 180(28,6 ± 3,2), 594 ± 197(10,8 ± 3,6) et de 283 ± 30(5,5 ± 3,6) μg (μ · kg−1), respectivement. De plus, la perte sanguine dans chaque groupe a été de 1461 ± 389, 805 ± 240 et de 931 ± 40 ml, respectivement.

Conclusion

Ladministration préanesthésique de clonidine diminue la dose de PGE 1 nécessaire à la production d’hypotension et réduit la perte sanguine pendant l’opération.

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Copyright information

© Canadian Anesthesiologists 1999

Authors and Affiliations

  • Kazuhiro Murakami
    • 1
  • Tadanori Mammoto
    • 1
  • Takashi Kita
    • 1
  • Yuichirou Imai
    • 1
    • 2
  • Takashi Mashimo
    • 1
    • 3
  • Tadaaki Kirita
    • 1
    • 2
  • Masahito Sugimura
    • 1
    • 2
  • Yoshihiko Kishi
    • 1
  1. 1.Department of AnesthesiologyOsaka Medical Center for Cancer and Cardiovascular DiseasesOsakaJapan
  2. 2.Department of Oral and Maxillofacial SurgeryNara Medical UniversityNara
  3. 3.Department of AnesthesiologyOsaka UniversityOsakaJapan

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