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Comparison of two and ten per cent rectal methohexitone for induction of anaesthesia in children

  • Robert B. Forbes
  • Gail E. Vandewalker
Article

Abstract

Plasma methohexitone concentrations were determined in 30 children, aged one to six years, who received 25 mg · kg-1 rectal methohexitone as either a two per cent or ten per cent solution for induction of anaesthesia. Venous blood samples were obtained 15, 30, 45 and 120 minutes following drug administration, Twenty-six of 30 children were asleep within fifteen minutes. Mean plasma methohexitone concentrations were 5.39, 4.42, 3.40 and 1.54 μg·ml-1 at 15, 30, 45 and 120 minutesfollowing administration of two per cent methohexitone. Use of the ten per cent solution resulted in mean plasma methohexitone concentrations of 3.81, 3.12, 2.31 and 1.07 μg · ml-1 at the same time intervals. Plasma methohexitone concentrations were significantly higher at 15, 30 and 45 minutesfollowing administration of two per cent methohexitone, when compared to the ten per cent solution.

Key words

ANAESTHESIA: paediatric PHARMACOKINETICS: methohexitone premedication RECTAL: methohexitone 

Résumé

Les concentrations plasmatiques de méthohexitone ont été déterminées chez 30 enfants âgés de un à six ans ayant reçu 25 mg · kg-1 de méthohexitone par voie rectale soit en solution de deux ou de dix pour cent pour ľinduction de ľanesthésie. Les échantillons veineux sanguins ont été obtenus en 15, 30, 45 et 120 minutes après ľadministration du médicament. Vingt-six des 30 enfants furent endormis en dedans de quinze minutes. Les concentrations plasmatiques moyennes de méthohexitone étaient de 5.39, 4.42, 3.40 et 1.54 mg·ml-1 à 15, 30, 45 et 120 minutes après ľadministration de deux pour cent de méthohexitone. Ľutilisation ďune solution de méthohexitone à dix pour cent a amené des concentrations moyennes plasmatiques de méthohexitone de 3.80 à 3.12, 2,31 et 1.07 mg·ml-1 aux mêmes intervalles. Les concentrations plasmatiques de méthohexitone étaient significativement supérieures 15, 30 et 45 minutes après ľadministration de deux pour cent de méthohexitone comparativement à la solution de dix pour cent.

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Copyright information

© Canadian Anesthesiologists 1988

Authors and Affiliations

  • Robert B. Forbes
    • 1
  • Gail E. Vandewalker
    • 1
  1. 1.Department of AnesthesiaUniversity of Iowa College of MedicineIowa City

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