Canadian Journal of Anaesthesia

, Volume 39, Issue 4, pp 398–400 | Cite as

Anaesthesia for charcot-marie-tooth disease: a review of 86 cases

  • Joseph F. Antognini
Clinical Reports


Operative charts were reviewed in 86 patients with Charcot-Marie-Tooth disease, a condition characterized by chronic muscular denervation. A total of 161 surgical procedures was performed. Major complications were few, and only one operative death occurred, unrelated to anaesthesia. Succinylcholine and malignant hyperthermia triggering agents were used in 41 (48%) and 77 (90%) patients, respectively, without untoward effects. Contrary to previous reports, this survey supports the safe use of succinylcholine and MH triggering agents in this disease.

Key words

Anaesthesia muscle: denervation syndromes: Charcot-Marie-Tooth disease 


La maladie de Charcot-Marie-Tooth se caractérise par une dénervation musculaire chronique. Les dossiers anesthésiques de 86 patients atteints de cette maladie ont été revus. Les patients avaient subi un total de 161 interventions chirurgicales. Il y à eu peu de complications majeures, et un seul décès périopératoire sans relation avec l’anesthésie. La succinylcholine a été utilisée chez 41 (48%) patients et d’autres agents susceptibles d’induire une hyperthermie maligne ont servi pour anesthésier 77 (90%) patients. Aucun effet indésirable dû à ces médicaments n’a été observé. Contrairement à d’autres observations cliniques, cette étude rétrospective suggère que la succinylcholine et les agents inducteurs d’hyperthermie maligne peuvent être utilisés sans augmenter le risque de complication chez les patients atteints de cette maladie.


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Copyright information

© Canadian Anesthesiologists 1992

Authors and Affiliations

  • Joseph F. Antognini
    • 1
  1. 1.Department of AnesthesiologyUniversity of California, Davis Medical CenterSacramento

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