Canadian Anaesthetists’ Society Journal

, Volume 32, Issue 1, pp 53–55 | Cite as

Hepatitis due to repeated inhalation of methoxyflurane in subanaesthetic concentrations

  • Tadao Okuno
  • Makoto Takeda
  • Masahide Horishi
  • Takeshi Okanoue
  • Tatsuro Takino


The authors present a case of hepatitis, which wasdue to repeated self-administered inhalation of methoxyflurane in subanaesthetic concentrations for insomnia. The diagnosis of viral hepatitis, type A or type B, was excluded on the basis of serologic findings. This case is of particular interest in that methoxyflurane even in subanaesthetic concentrations caused hepatic damage on repeated exposure.

Key words

Anaesthetics: methoxyflurane abuse Liver: hepatitis 


Les auteurs rapportent un cas d’hépatite due à l’administration répétée de methoxyflurane en concentrations subanesthésiques contre l’insomnie. Le diagnostic d’hépatite virale type A ou type B a été éliminé par ïinvestigation sérologique. Ce cas apparaît d’un grand intérêt car il montre que le methoxyflurane, en doses subanesthésiques administrées de façon répétée, peut causer des dommages hépatiques.


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Copyright information

© Canadian Anesthesiologists 1985

Authors and Affiliations

  • Tadao Okuno
    • 1
  • Makoto Takeda
    • 1
  • Masahide Horishi
    • 1
  • Takeshi Okanoue
    • 1
  • Tatsuro Takino
    • 1
  1. 1.Third Department of Internal MedicineKyoto Prefectural University of MedicineKyotoJapan

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