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Annals of Nuclear Medicine

, Volume 17, Issue 7, pp 609–611 | Cite as

Neurofibroma with increased uptake of [F-18]-fluoro-2 deoxy-d-glucose interpreted as a metastatic lesion

  • Chung-Huei HsuEmail author
  • Chi-Ming Lee
  • Fong-Chieh Wang
  • Chia-Lang Fang
Case Report

Abstract

We report a patient with a solitary spinal neurofibroma in the posterior mediastinum interpreted as a metastatic tumor.

A 46-year-old female with rectal cancer who had undergone operation and subsequent adjuvant chemotherapy two years previously was referred to our department for a follow-up whole body FDG-PET study. PET scan revealed a mass with increased uptake of FDG (SUV=4.6) in the posterior mediastinum. MRI examination showed a dumbbell neurogenic tumor originating from the intercostal nerve at T6 level. A subsequent CT-guided biopsy demonstrated a neurofibroma.

Key words

neurofibroma FDG PET 

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References

  1. 1.
    Cook GJ, Fogelman I, Maisey MN, et al. Normal physiological and pathological variants of 18-fluoro-2-deoxyglucose positron-emission tomography scanning: potential for error in interpretation.Semin Nucl Med 1996; 26: 308–314.PubMedCrossRefGoogle Scholar
  2. 2.
    Ferner RE, O’Doherty MJ. Neurofibroma and schwannoma.Curr Opin Neurol 2002; 15: 679–684.PubMedCrossRefGoogle Scholar
  3. 3.
    Khong PL, Goh WH, Wong VC, Fung CW, Ooi GC. MR imaging of spinal tumors in children with neurofibromatosis I.AJR 2003; 180: 413–417.PubMedGoogle Scholar
  4. 4.
    Zhuang H, Alavi A. 18-fluorodeoxyglucose positron emission tomographic imaging in the detection and monitoring of infection and inflammation.Semin Nucl Med 2002; 32: 47–59.PubMedCrossRefGoogle Scholar
  5. 5.
    Ichiya Y, Kuwabara Y, Sasaki M, Yoshida T, Akashi Y, Murayama S, et al. FDG-PET in infectious lesions: The detection and assessment of lesion activity.Aun Nucl Med 1996; 10: 185–191.CrossRefGoogle Scholar
  6. 6.
    Knight SB, Delbeke D, Stewart JR, et al. Evaluation of pulmonary lesions with FDG-PET. Comparison of findings in patients with and without a history of prior malignancy.Chest 1996; 109: 982–988.PubMedCrossRefGoogle Scholar
  7. 7.
    Yang SN, Liang JA, Lin FJ, Kwan AS, Kao CH, Shen YY. Differentiating benign and malignant pulmonary lesions with FDG-PET.Anticancer Res 2001; 21: 4153–4157.PubMedGoogle Scholar
  8. 8.
    Hsu WH, Hsu NY, Shen YY, Yen RF, Kao CH. Differentiating solitary pulmonary metastases in patients with extrapulmonary neoplasms using FDG-PET.Cancer Invest 2003; 21: 47–52.PubMedCrossRefGoogle Scholar
  9. 9.
    Loannidis JP, Lau J.18F-FDG PET for the diagnosis and grading of soft-tissue sarcoma: a meta-analysis.J Nucl Med 2003; 44: 717–724.Google Scholar
  10. 10.
    Aoki J, Watanabe H, Shinozaki T, Takagishi K, Tokunaga M, Koyama Y, et al. FDG-PET for preoperative differential diagnosis between benign and malignant soft tissue masses.Skeletal Radiol 2003; 32: 133–138.PubMedCrossRefGoogle Scholar
  11. 11.
    Dimitrakopoulou-Strauss A, Strauss LG, Schwarzbach M, Burger C, Heichel T, Willeke F, et al. Dynamic PET18F-FDG studies in patients with primary and recurrent softtissue sarcomas: impact on diagnosis and correlation with grading.J Nucl Med 2001; 42: 713–720.PubMedGoogle Scholar
  12. 12.
    Gabriel M, Erler H, Donnemiller E, Riccabona G. Increased F-18 fluorodeoxyglucose accumulation in a benign neurofibroma—a pitfall in a patient with thyroid cancer: a case report.Nuklearmedizin 2002; 41: N14–15.PubMedGoogle Scholar
  13. 13.
    Kubota K, Yamada S, Kondo T, Yamada K, Fukuda H, Fujiwara T, et al. PET imaging of primary mediastinal tumors.Br J Cancer 1996; 73: 882–886.PubMedCrossRefGoogle Scholar
  14. 14.
    Ahmed AR, Watanabe H, Aoki J, Shinozaki T, Takagishi K. Schwannoma of the extremities: the role of PET in preoperative planning.Eur J Nucl Med 2001; 928: 1541–1551.CrossRefGoogle Scholar
  15. 15.
    Ferner RE, Lucas JD, O’Doherty MJ, Hughes RA, Smith MA, Cronin BF, et al. Evaluation of (18)fluorodeoxy-glucose positron emission tomography ((18)FDG PET) in the detection of malignant peripheral nerve sheath tumours arising from within plexiform neurofibromas in neurofibromatosis 1.J Neurol Neurosurg Psychiatry 2000; 68: 353–35.PubMedCrossRefGoogle Scholar
  16. 16.
    Solomon SB, Dogan AS, Nicol TL, Campbell JN, Pomper MG. Positron emission tomography in the detection and management of sarcomatous transformation in neurofibromatosis.Clin Nucl Med 2001; 26: 525–526.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2003

Authors and Affiliations

  • Chung-Huei Hsu
    • 1
    Email author
  • Chi-Ming Lee
    • 2
  • Fong-Chieh Wang
    • 3
  • Chia-Lang Fang
    • 4
  1. 1.PET CenterTaipei Medical University HospitalTaipeiTaiwan
  2. 2.Department of RadiologyTaipei Medical University HospitalTaipeiTaiwan
  3. 3.Department of Internal MedicineTaipei Medical University HospitalTaipeiTaiwan
  4. 4.Department of PathologyTaipei Medical University HospitalTaipeiTaiwan

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