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Annals of Nuclear Medicine

, Volume 17, Issue 5, pp 403–406 | Cite as

High [18F] 2-fluoro-2-deoxy-d-glucose (FDG) uptake of adrenocortical adenoma showing subclinical Cushing's syndrome

  • Akiko Shimizu
  • Noboru Oriuchi
  • Yoshito Tsushima
  • Tetsuya Higuchi
  • Jun Aoki
  • Keigo Endo
Case Reports

Abstract

A 48-year-old woman with left adrenal tumor, which showed increased uptake of [18F] 2-fluoro-2-deoxy-d-glucose (FDG) was presented. Her adrenal tumor was incidentally discovered, although she had no remarkable illness, and her blood pressure was normal. Hormonal examination including dexamethason suppression test and diurnal variation in serum cortisol level confirmed preclinical Cushing's syndrome. CT, MRI and131I-adosterol scintigraphy showed findings consistent with adenoma. FDG-PET revealed that tumor had standardized uptake value of 4.8, which was higher than usual benign tumors. Histological diagnosis of the resected adrenal tumor was adrenocortical adenoma without evidence of malignancy. Although the current literature showed that adenomas in general did not exhibit increased FDG uptake, adenoma in the present case with subclinical Cushing's syndrome showed intense uptake of FDG, suggesting FDG-PET could evaluate hormonal function of an adrenocortical adenoma in a completely asymptomatic normocortisolism patient.

Key words

FDG-PET preclinical Cushing's syndrome adrenocortical adenoma adrenal incidentaloma 

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References

  1. 1.
    Maurea S, Mainolfi C, Bazzicalupo L, Panico MR, Lyparato C, Alfano B, et al. Imaging of adrenal tumors using FDG PET: comparison of benign and malignant lesions.AJR 1999; 173: 25–29.PubMedGoogle Scholar
  2. 2.
    Yun M, Kim W, Alnafisi N, Lacorte L, Jang S, Alavi A.18F-FDG PET in characterizing adrenal lesions detected on CT or MRI.J Nucl Med 2001; 42: 1795–1799.PubMedGoogle Scholar
  3. 3.
    Lin EC, Heigans R. Adrenal hyperplasia in Cushing's syndrome demonstrated by FDG positron emission tomographic imaging.Clin Nucl Med 2002; 27: 516–517.PubMedCrossRefGoogle Scholar
  4. 4.
    Tushima Y, Ishizaka H, Matsumoto M. Adrenal masses: Differentiation with chemical shift, fast low-angle shot MR imaging.Radiology 1993; 186: 705–709.Google Scholar
  5. 5.
    Rossi R, Tauchmanova L, Luciano A, Di Martino M, Battista C, Del Viscovo L, et al. Subclinical Cushing's syndrome in patients with adrenal incidentaloma: Clinical and biochemical features.J Clin Endocrinol Metab, 2000; 85: 1440–1448.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2003

Authors and Affiliations

  • Akiko Shimizu
    • 1
  • Noboru Oriuchi
    • 1
  • Yoshito Tsushima
    • 2
  • Tetsuya Higuchi
    • 1
  • Jun Aoki
    • 1
  • Keigo Endo
    • 1
  1. 1.Department of Diagnostic Radiology and Nuclear MedicineGunma University School of MedicineMaebashi, GunmaJapan
  2. 2.Department of RadiologyMotojima General HospitalMotojimaJapan

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