Imaging of adenosine A1 receptors in the human brain by positron emission tomography with [11C]MPDX
- Cite this article as:
- Fukumitsu, N., Ishii, K., Kimura, Y. et al. Ann Nucl Med (2003) 17: 511. doi:10.1007/BF03006445
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We report the first clinical PET study using [1-methyl-11C]8-dicyclopropylmethyl-1-methyl-3-propylxanthine ([11C]MPDX) for imaging adenosine A1 receptors in the human brain. The binding of [11C]MPDX evaluated quantitatively as the distribution volume by a graphical analysis was high in the striatum and thalamus, and low in the cerebellum. The distribution pattern of [11C]MPDX was coincident with that of adenosine A1 receptorsin vitro reported previously, and was different from those of blood flow and [18F]FDG. The [11C]MPDX PET has the potential for mapping adenosine A1 receptors in the human brain.