Summary
A controlled study was undertaken in man to evaluate glycopyrrolate as a substitute for atropine in anaesthesia by determining the relative ability of the two drugs to protect against the cholinergic challenge provided by neostigmine administered at the conclusion of anaesthesia for reversal of neuromuscular blockade. Results indicate that glycopyrrolate offers the same protection against neostigmine-induced bradycardia as atropine with a marked reduction in the magnitude of the initial tachycardia. The dose of glycopyrrolate required to do this is 0.2 mg for each 1 mg of neostigmine administered, which is half the dose of atropine required for the same purpose.
Résumé
Nous avons fait, chez ľhomme, une ľtude avec tľmoin pour dľterminer si le glyeopyrrolate pourrait remplacer ľatropine en anesthésie; ľétude a porté sur ľhabilité relative des deux médicaments de protéger contre la prédominance cholinergique produite par ľadministration de néostigmine à la fin de ľanesthésie pour corriger le blocage neuromusculaire. Les résultats démontrant que le glyeopyrrolate offre la méme protection que ľatropine contre la bradycardie produite par la néostigmine et ľimportance de la tachycardie initiale est de beaucoup réduite. La dose de glyeopyrrolate requise pour obtenir cet effet est de 0.2 mg pour chaque mg de néostigmine donné ce qui équivaut à la moitié de la dose ďatropine nécessaire pour obtenir le même effet.
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Ramamurthy, S., Shaker, M.H. & Winnie, A.P. Glycopyrrolate as a substitute for atropine in neostigmine reversal of muscle relaxant drugs. Canad. Anaesth. Soc. J. 19, 399–411 (1972). https://doi.org/10.1007/BF03005964
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DOI: https://doi.org/10.1007/BF03005964