Canadian Anaesthetists’ Society Journal

, Volume 22, Issue 3, pp 339–348 | Cite as

The cardiovascular effects of ketamine in hypotensive states

  • David H. W. Wong
  • Leonard C. Jenkins


Ketamine was found to raise the systemic arterial blood pressure but not necessarily the perfusion in hypovolaemic states. However, in hypotensive states of short duration from endotoxin treatment, it improved the haemodynamics with increase in both the perfusion and the systemic pressure. The implications of these observations for clinical situations were discussed.


Cardiac Output Ketamine Arterial Blood Pressure Indocyanine Green Haemodynamic Parameter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


En mesurant la tension artérielle, la pression veineuse centrale et le débit cardiaque, les auteurs ont démontré que la Kétamine en présence de choc hypovolhémique, élève la tension artérielle sans nécessairement améliorer la perfusion; cependant au cours d’hypotension de courte durée, induite par injection d’endo-toxine, la Kétamine améliore et la perfusion et la tension artérielle systémique.

Les applications cliniques de ces constatations sont discutées.


  1. 1.
    Corssen, G., Allarde, R., Brosch, F., &Arbenz, G. Ketamine as the sole anesthetic in open-heart surgery. A preliminary report. Anesthesia and Analgesia (Cleveland),49: 1025 (1970).Google Scholar
  2. 2.
    Dawson, B., Siker, E.S., &Wilson, R.D. Would you please summarize the current usefulness of ketamine in anesthetic practice? (Question with Answers), Anesthesia and Analgesia (Cleveland),50: 1056 (1971).Google Scholar
  3. 3.
    Cohssen, G. Ketamine for high-risk cardiac patients. Anesthesiology36: 413 (1972).CrossRefGoogle Scholar
  4. 4.
    Abbey, N.D. Ketamine (Letter to the Editor), Canadian Medical Association Journal106: 749 (1972).PubMedGoogle Scholar
  5. 5.
    Virtue, R.W., Alanis, J.M., Mori, M., Lafarque, R.T., Vogel, J.H.K., &Metcalf, D.R. An anesthetic agent: 2-orthochlorophenyl, 2-methylamino cyclohexanone HC1 (Cl-581). Anesthesiology28: 823 (1967).PubMedCrossRefGoogle Scholar
  6. 6.
    Altman, P.L. &Dittmer, D.S. (Ed.), Biology Data Book, Federation of American Societies for Experimental Biology, Washington, D.C., p. 264 (1964).Google Scholar
  7. 7.
    Bovill, J.G., Clarke, R.S.J., Davis, E.A., &Dundell, J.W. Some cardiovascular effects of ketamine in man. British Journal of Pharmacology41: 411P (1971).Google Scholar
  8. 8.
    Traber, D.L., Wilson, R.D., &Priano, L.L. Blockade of the hypertensive response to ketamine. Anesthesia and Analgesia (Cleveland),49: 420 (1970).Google Scholar
  9. 9.
    Wilson, R.D., Traber, D.L., &McCoy, N.R. Cardiopulmonary effects of CI-581 — the New Dissociative Anesthetic, Southern Medical Journal61: 692 (1968).PubMedGoogle Scholar

Copyright information

© Canadian Anesthesiologists 1975

Authors and Affiliations

  • David H. W. Wong
    • 1
  • Leonard C. Jenkins
    • 1
  1. 1.Department of Anaesthesia and Experimental Research LaboratoryUniversity of British ColumbiaUSA

Personalised recommendations