Clinical trial of ketamine (ci-581): A preliminary report

  • S. A. Oduntan
  • R. Y. Gool
Article

Summary

Ketamine (cI-581) is a derivative of phencyclidine. It produces analgesia and anaesthesia very rapidly, has a short duration of action, and is rapidly metabolized in the body. For this reason it has been used for continuous intravenous infusion or intermittent intravenous injections. It increases blood pressure and heart rate slightly. Respiration has not been found to be depressed during its use.

A report of the use of Ketamine in 100 consecutive patients is presented. Many of these patients were considered poor risks, and it is felt that Ketamine provided a greater margin of safety than conventional anaesthesia would have done. The dose used for induction was 1-1.25 mg/kg, while the maintenance dose was 1.5-2 mg/kg/hour.

Résumé

La Kétamine (ci-581) est un dérivé de la phencyclidine. Elle produit ľanalgésie et ľanesthésie très rapidement, son action est de courte durée et elle est métabolisée rapidement. C’est pourquoi on ľa utilisé en perfusion veineuse continue ou en injections intraveineuses intermittentes. Elle produit une légère élévation de la pression sanguine et du rythme cardiaque. On n’a pas observé de dépression respiratoire pendant son utilisation.

On présente un rapport sur ľusage de la Kétamine pour 100 cas consécutifs. Plusieurs des malades étaient considérés comme de mauvais risques et il semble que la Kétamine a procuré une marge de sécurité supérieure à celle de ľanesthésie conventionnelle chez ces malades. La dose utilisée pour ľinduction a été de 1-1.25 mg/kg alors que la dose d'entretien a été de 1.5-2 mg/kg/heure.

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Copyright information

© Canadian Anesthesiologists 1970

Authors and Affiliations

  • S. A. Oduntan
    • 1
  • R. Y. Gool
    • 1
  1. 1.Department of AnaesthesiaUniversity College HospitalIbadanNigeria

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