Canadian Anaesthetists’ Society Journal

, Volume 12, Issue 5, pp 486–498

Succinylcholine and acetazolamide (Diamox) in anaesthesia for ocular surgery

  • Arthur S Carballo
Article

Summary

A review of the physiology and pharmacology of intraocular pressure as related to anaesthesia has been presented A study has been undertaken to determine whethei previously administered acetazolamide would prevent the dangerous rise in intraocular pressure accompanying the use of succinylcholine in anaesthesia, so that succinylcholine might be safely employed in cataract extractions and coineal transplants, and m patients suffering from glaucoma

The ocular tensions of two series of 25 anaesthetized patients, have been studied Acetazolamide (Diamox) and succinylcholine were given to the test group, and succmylcholme only to the control group The mean values of the successive readings, the standard deviations, and the upper and lower limits of the basal observations have been calculated The results are given in tables and the mean values are expressed graphically to facilitate their comparison

Significant deviations have been found after succmylcholime alone, but not when acetazolamide was given before the succmylcholme The readings m the test group remained within the accepted normal limits for the intraocular tension

This study theiefore indicates the practical value of acetazolamide as a means of avoiding the significant elevations in intraocular tensions produced by succinylchohne

Résumé

Nous avons présenté une revua de la physiologie et de la pharmacologie de la pression mtraoculaire en rapport avec 1’anesthésie Nous avons entrepris une étude pour préciser si l’admmistraiion préalable d’acétazolamide (Diamox) pourrait prévenir l’élévation dangereuse de la pression mtraqculaire qui accompagne l’usage de la succinylcholine am cours de l’anesthésie De cette façon, il serait possible d’employer la succmylchohne, en toute sécurité, au cours de l’extraction de cataractes, de greffes de cornée et chez les maladies qui souffrent de glaucome

Nous avons étudié les tensions oculaires de deux séries de 25 malades anesthésiés Nous avons donné l’acétazoliamide (Diamox) et la succinylchohne au groupe à l’étude et la succmylcholme seule au groupe contrôlé Nous avons calculé les valeurs moyennes des lectures successives, les déviations standards, les limites supérieures et inférieures des observations de base Nous donnons les résultats sur les tableaux et, pour facihter lew comparaison, nous exprimons les valeurs moyennes par des graphiques Nous avons observé des variations importantes lorsque la succmylcholme était employée seule, mais non dafys la série de sujets étudiés, chez qui l’acétazolamide avant été donnée avant la supcinylcholme Chez ce dernier groupe, les lectures sont demeuiées dans les hmites normales acceptées pour la tension intraoculaire

En conséquence, il semble biee quje cette étude prouve la valeur pratique de l’acétazolamide (Diamox) comme moyen d’éviter les élévations importantes intraoculaires produites par la succinylchohne

References

  1. 1.
    LINCOFF, H A, Breinin, G M, &DeVoe, A G The Effect of Succmylcholme on the Extraocular Muscles Am J Opth43 440 (1947)Google Scholar
  2. 2.
    Schwartz, H &De ROeth, A Effect of Intraocular Pressure in Human Beings Anesthesiology19 112 (1958)CrossRefGoogle Scholar
  3. 3.
    Atkinson, W S Anesthesia for Glaucoma Surgery New York J Med56 205 (1956)PubMedGoogle Scholar
  4. 4.
    Lewallen, W M &Hicks, B L The Use of Succmylcholme mOcular Surgery Am J Ophth49 773 (1960)PubMedGoogle Scholar
  5. 5.
    Mietus, C A, Hague, E B, &CarboIne, D J Use of General Anesthesia and Muscle Relaxants m Cataract Surgery Am J Ophth47 487 (1959)PubMedGoogle Scholar
  6. 6.
    Riwchun, M H Choice of Anesthesia m Ophthalmic Surgery Anaesth & Analg37 75 (1958)Google Scholar
  7. 7.
    Roche, J R Research m the Use of Curare for Ocular Surgery Am J Ophth33 91 (1950)PubMedGoogle Scholar
  8. 8.
    François, J, Neetens, A, &GGllette, J M Microradiiographic Study of the Inner Wall of the Schlemm’s Canal Am J Ophth40 491 (1955)Google Scholar
  9. 9.
    Friedenwald, J S Formation of the Intraocular Fluid Am J Ophth32 9 (1949)Google Scholar
  10. 10.
    Friedenwald, J S &Stiehler. R D Circulation of Aqueous vii A Mechanism of Secretion of the Intraocular Fluid A M A Arch Ophth20 761 (1938)Google Scholar
  11. 11.
    Wright, S Applied Physiology, 10th ed London Oxford Univ Press (1962)Google Scholar
  12. 12.
    Adler, F H Physiology of the Eye Clinical Application 3rd ed St Louis Mosby (1959)Google Scholar
  13. 13.
    — Textbook of Ophthalmology, 7th ed Philadelphia Saumders (1962)Google Scholar
  14. 14.
    Kinsey, V E Comparative Chemistry of Aqueous Humour m Posterior and Anterior Chambers of Rabbit Eye A M A Arch Ophth50 401 (1953)Google Scholar
  15. 15.
    Galin, M A &Davidson, R Diuretics m Ophthalmology New York J Med62 2831 (1962)Google Scholar
  16. 16.
    Duncalf, D &Weitzner, S W Ventilation and Hypercapnea on Intraocular Pressure Anaesth & Analg42 232 (1963)Google Scholar
  17. 17.
    Macri, F J Vascular Pressure Relationships and the Intralocular Pressure A M A Arch Ophth65 571 (1961)Google Scholar
  18. 18.
    Atkinson, W S Local Anesthesia m Ophthalmology Am J Ophth31 1607 (1948)PubMedGoogle Scholar
  19. 19.
    Becker, B Annual Review of Glaucoma, 1955–1956 A M A Arch Ophth56 898 (1956)PubMedGoogle Scholar
  20. 20.
    DelPizzo, A &Guida, F Succinylcholine m Cataract Surgery Anaesth & Analg40 686 (1961)Google Scholar
  21. 21.
    Everett, W G, Vey, E K, &Veenis, C Y Factors in Reducing Ocular Tension prior to Intraocular Surgery Tr Am Acad Ophth63 286 (1959)Google Scholar
  22. 22.
    Grifford, H A Study of the Effect of Retrobulbar Anesthesia in the Ocular Tension and the Vitreous Pressure Am J Ophth32 1359 (1949)Google Scholar
  23. 23.
    Kirsch, R E &Steinman, W Digital Pressure, an Important Safeguard m Cataract Suigery A M A Arch Ophth54 697 (1955)PubMedGoogle Scholar
  24. 24.
    Snydacker, D, Deutsch, W E, &Bayard, W Various Anesthetic Agents Used in Retrobulbar Injections A M A Arch Ophth51 473 (1954)Google Scholar
  25. 25.
    Becker, B &Chriestensen, R E Water Drinking and Tonography in the Diagnosis of Glaucoma A M A Arch Ophth56 321 (1956)PubMedGoogle Scholar
  26. 26.
    Galin, M A, Aizawa, F, &McLean, J M Evaluation ol the Water Provocative Test Am J Ophth51 451 (1961)Google Scholar
  27. 27.
    Galin, M A, Aizawa, F, &McLean, J M The Water provocative Test in Glaucomatous Patients Am J Ophth52 15 (1961)PubMedGoogle Scholar
  28. 28.
    Kornblueth, W, AladjemQff, L, Magora, F, &Gabbay, A Influence of General Anesthesia on Intraocular Pressure in Man A M A Aich Ophth61 84 (1959)Google Scholar
  29. 29.
    Schmerl, E &Steinberg, B Role of the Diencephalon m Regulating Ocular Tension Am J Ophth31 155 (1948)PubMedGoogle Scholar
  30. 30.
    — Determination of Ocular Tension and Rigidity in Rabbits Am J Ophth29 1400 (1946)PubMedGoogle Scholar
  31. 31.
    — Central Control of Intraocular Pressure by Active Principles Am J Ophth31 1097 (1948)PubMedGoogle Scholar
  32. 32.
    von Sallman, L, Macri, F J, Wanko, T, &Grimes, P A Some Mechanisms of Centrally Induced Eye Pressure Responses Am J Ophth42 130 (1956)Google Scholar
  33. 33.
    vonSallmann, L & Lovenstein Responses of Intraocular Pressure, Blood Pressulre and Cutaneous Vessels to Electnc Stimulation in the piencephalon Am J Ophth39 11 (1955)Google Scholar
  34. 34.
    Moses, R A &Becker, B Clinical Tonography, TheJ Scleral Rigidity Correction Am J Ophth45 196 (1958)PubMedGoogle Scholar
  35. 35.
    Adriani, J The Pharmacology of Anesthetic Drugs, 4th ed Springfield Thomas (1960)Google Scholar
  36. 36.
    Comroe, J H Jr &Dripps, R D Histamine-Like Action of Curare and Tubocurarine Injected Intracutaneously and Intraartenally in Man Anesthesiology7 260 (1946)CrossRefGoogle Scholar
  37. 37.
    Magora, F &Collins, V J The Influence of General Anesthetic Agents on Intraocular Pressure in Man A M A Arch Ophth66 806 (1901)Google Scholar
  38. 38.
    Schwartz, H Chloroform Anesthesia for Ophthalmic Examination Am J Ophth43 27 (1957)PubMedGoogle Scholar
  39. 39.
    Wynands, J E &CroweIX, D E Inilraocular Tension in Association with Succinylchohne and Endotracheal Intubation A. Preliminary Report Candd Anaesth Soc J7 39 (1960)Google Scholar
  40. 40.
    DeRoetth, A Jr &Schwartz, H Aqueous Humour Dynamics in Glaucoma A M A Arch Ophth55 755 (1956)Google Scholar
  41. 41.
    Lund, P C Surital Sodium A New Inlitravenous Anesthetic Agentj Am J Surg82 637 (1951)CrossRefGoogle Scholar
  42. 42.
    Thomas, G J &McCaslin, M F Pentothal Sodium in Ophthalmic Surgery A M A Arch Ophth37 452 (1947)Google Scholar
  43. 43.
    Goth, A Medical Pharmacology, 1st ed ISt Louis Mosby (1961)Google Scholar
  44. 44.
    Barnett, A Ocular Effects of Methonium Compounds Brit J Ophth36 593 (1952)PubMedCrossRefGoogle Scholar
  45. 45.
    Colle, J C, Duke-Elder, P M, &Duke-Elder, W S Studies on the Intraocular Pressure J Physiol71 1 (1931)PubMedGoogle Scholar
  46. 46.
    Friedenwald, J S &Buschke, W The Role of Epinephnne m the Formation of the Intraocular Fluid Am J Ophth24 1105 (1941)Google Scholar
  47. 47.
    Leopold, I H, Hedges, T R Jr,Montana, J, &Krishna, N Local Administration of Antichohnesterase Agents in Ocular Myasthenia Gravis A M A, Arch Ophth63 544 (1960)Google Scholar
  48. 48.
    Adamson, D C &Kinsman, F M Sbccinylchokne Chloride m Anaesthesia Anaesthesia7 166 (1952)PubMedCrossRefGoogle Scholar
  49. 49.
    Agarwal, L P &Mathur, S P, Culrare in Ocular Surgery Report of 25 Cases Brit J Ophth36 603 (1952)PubMedCrossRefGoogle Scholar
  50. 50.
    Bourne, J G, Collier, H O J, &SUmmers, G F Succinylchcpline (Succmoylchohne) Muscle-Relaxant of Short Action Lancet1 1225 (1952)PubMedCrossRefGoogle Scholar
  51. 51.
    vonDardel, O &Thesleff, S Clinical Experience with Succiniylcholme Iodide A New Muscular Relaxant Anaesth &Analg31 250 (1952)Google Scholar
  52. 52.
    Dillon, J B, Sabawala, P, Taylor, D B, &Gunter, R Depolarizing Neuromuscular Blocking Agents and Intraocular Pressure m Vivo Anesthesioldgy18 439 (1957)Google Scholar
  53. 53.
    — Action of Succmylcholine on Extrajocular Muscles and Intraocular Pressure Anesthesiology18 44 (1957)PubMedGoogle Scholar
  54. 54.
    Drucker, A P, Sadove, M S, &Unna, K R Ophthalmic Studies of Curare and Curare-Like Drugs in Man Am J Ophth34 543 (1951)Google Scholar
  55. 55.
    Harris, L C &Dripps, R D Use of Decamethomum Bromide for the Production of Muscular Relaxation Anesthesiology11 215 (1950)PubMedGoogle Scholar
  56. 56.
    Calvert, R &Morgan, D K Effect of Suxamethomum on Blood pressure Anaesthesia9 196 (1954)PubMedCrossRefGoogle Scholar
  57. 57.
    Craythorne, N W B, Rottenstein, H S, &Dripps, R D The Effect of Succmylcholme on Intraocular Pressure in Adults, Infants and Children during General Anesthesia Anesthesiology21 59 (1960)PubMedCrossRefGoogle Scholar
  58. 58.
    Duke-Elder, S W &Duke-Elder, P M The Clinical Significance of the Ocular Musculature with Special Reference to the Intraocular Pressure and the Circulation of the Intraocular Fluid Brit J Ophth16 321 (1932)CrossRefGoogle Scholar
  59. 59.
    Kinsey, V E A Unified Concept of Aqueous Humour Dynamics alnd the Maintenance of Intraocular Pressure A M A Arch Ophth44 215 (1950)Google Scholar
  60. 60.
    Lincoff, H A, Ellis, C H, DeVoe, A G, & DeBeer, E The Effect of Succmylcholme on Intraocular Pressure Am J Oplith40 501 (1955)Google Scholar
  61. 61.
    Macri, F J Acetazolamide and the Venous Pressure of the Eye A M A Arch Ophth63 953 (1960)Google Scholar
  62. 62.
    Breinin, G M &Moldaver, J Electromyography of the Human Extraocular Muscles A M A Arch Ophth54 200 (1955)PubMedGoogle Scholar
  63. 63.
    Breinin, G M The Position of Rest Inuring Anesthesia and Sleep Electromyographic Observations A M A Arch Ophth57 323 (1957)PubMedGoogle Scholar
  64. 64.
    Marg, E, Jampolsky, A, &Tamler, E Elements of Human Extraocular Electromyography A M A Arch Ophth61 2J58 (1959)Google Scholar
  65. 65.
    Sobel, A M Hexafiuoremum, Succmylcholme and Intraocular Tension Anaesth & Analg41 399 (1962)CrossRefGoogle Scholar
  66. 66.
    Wahlin, A Clinical and Experimental Studies on Effects of Succmylcholine Acta Anaesth Scandmav Supplement v (June, 1960)Google Scholar
  67. 67.
    Wretland, A &Wahlin, A The Effect of Succmylcholine on the Orbital Musculature of the Cat Acta Anaesth Scandmav3, 101 (1959)CrossRefGoogle Scholar
  68. 68.
    Cameron, A &Burn, R A Hexamethomum and Glaucoma Brit J Ophth36 482 (1952)PubMedCrossRefGoogle Scholar
  69. 69.
    Clark, W B &Duggan, J W The Use of Dibenamime in the Treatment of Acute Congestive Glaucoma Am J Ophth34 535 (1951)PubMedGoogle Scholar
  70. 70.
    Cordaro, V F &Arrowwood, J G Mylaxen Preliminary Clinical Evaluation of a New Agent for Neuromuscular Blockade Anaesth fc Analg34 112 (1955)Google Scholar
  71. 71.
    Fajardo, R V, Hamilton, R, &Leopold, I H The Effect of Hydrochiorothiazide (Esidrex)on Intraocular Pressure m Man Am J Ophth49 1321 (1960)PubMedGoogle Scholar
  72. 72.
    Foldes, F F, Molloy, R E, Zsigmond, E K, &Zwart, J A Hexafluorenium Its Antichohnesterase and Neuromuscular Activity J Phartnacol Exper Therap129 400 (1960)Google Scholar
  73. 73.
    Foldes, F F, HILLMER, N R, Molloy, R E, &Monte, A P Potentiation of the Neuromuscular Effect of Succinylcholme by Hexafluoremum Anesthesiology21 50 (1960)PubMedCrossRefGoogle Scholar
  74. 74.
    Galin, M A, Aizawa, F, &McLean, J M Intravenous Urea in the Treatmenl of Acute Angle-Closure Glaucoma Am J Ophth50 379 (1960)PubMedGoogle Scholar
  75. 75.
    GalEST, M A, McIvor, J W, &Magruder, G B Influence of Position m Intraocular Pressure Am J Ophth55 720 (1963)Google Scholar
  76. 76.
    Gartner, S Methods of Inducing Anesthesia and Hypotony for Cataract Surgery A M A Arch Ophth61 50 (1959)PubMedGoogle Scholar
  77. 77.
    Arruga, H Diamox in Ophthalmology Arch Soc Ophth Hispano-am15 374 (1955)Google Scholar
  78. 78.
    Bartolozzi, R &García-Alix, C Diamox m the Treatment of Glaucoma Preliminary Communication Arch Soc Ophth Hispano-am15 381 (1955)Google Scholar
  79. 79.
    Becker, B Decrease in Intraocular Pressure in Man by la Caibonic Anhydrase Inhibitor, Diamox Am J Ophth37 13 (1954)Google Scholar
  80. 80.
    Becker, B The Mechanism of the Fall m Intraocular pressure by the Carbonic Anhydrase Inhibitor, Diamox Am J Ophth39 177 (1955)Google Scholar
  81. 81.
    Grant, W M &Trotter, R R Diamox (Acetazoleamide) in the Treatment of Glaucoma A M A Arch Ophth51 335 (1954)Google Scholar
  82. 82.
    Green, H, Capper, Bocher, C A, &Leopold, I H The Effect of Diamox on the Carbonic Anhydrase Activity of the Anterior Uvea of the Rabbit Eye A M A Arch Ophth52 758 (1954)PubMedGoogle Scholar
  83. 83.
    Green, H, Bocher, C A, Calnan, A F, &Leopold, I H Carbonic Anhydrase and the Maintenance of Intra Ocular Tension A M A Arch Ophth53 463 (1955)Google Scholar
  84. 84.
    Kronfield, P C &Freeman, H M The Effect of Acletazolamide on the Response to Antenor Chamber Puncture in Man Am J Ophth50 1141 (1960)Google Scholar
  85. 85.
    Langham, M E Specificity and Comparative-Activity of the Carbonic Anhydrase Inhibitors Neptazane and Diamox on Animal and Human Eyes Brit J Ophth42 577 (1958)PubMedCrossRefGoogle Scholar
  86. 86.
    Macri, F J &Grimes, P A The Effects of Succinylcholme on the Extraocular Striate Muscles and on the Intraocular Pressure Am J Ophth44 221 (1957)PubMedGoogle Scholar
  87. 87.
    Sears, M L Intraocular Pressure of Unanesthetized Htyn Lack of Response to Acetazolamide A M A Arch Ophth63 212 (1960)Google Scholar
  88. 88.
    — Outflow Resistance of the Rabbit Eye Technique and Effects of Acetazolamide A M A Arch Ophth64 823 (1960)Google Scholar
  89. 89.
    Wistrand, P The Effect of Carbonic Anhydrase Inhibitor on Intraocular Pressure with Observations on the Pharmacology of Acetazolamide in the Rabbit Acta Pharmacol et Toxicol16 171 (1959)Google Scholar
  90. 90.
    MUIrhead, J F &Scheie, H G Transient Myopia aftjer Ac etazolamide A M A Arch Ophth63 315 (1960)Google Scholar
  91. 91.
    Alfano, J E &Clampit, J Injection of Hyaluromdasb into the Anterior Chamber of the Rabbit Eye Am J Ophth39 198 (1955)PubMedGoogle Scholar
  92. 92.
    Arstikatis, M &Hodgson, H The Effect of Lobotomy and Electroshock on Intraocular Pressure Am J Ophth35 3 (1952)Google Scholar
  93. 93.
    Becker, B &Fbiedenwald, J S Clinical Aqueous Outflow A M A Arch Ophth50 557 (1953)PubMedGoogle Scholar
  94. 94.
    Castillo, J C & DeBeer, E J Neuromuscular Blocking Action of Succinylcholme (Diacetylchohne) J Pharmacol & Exper Therap99 458 (1950)Google Scholar
  95. 95.
    Condon, H A General Anesthesia in Ophthalmic Surgery Brit J Ophth36 611 (1952)CrossRefGoogle Scholar
  96. 96.
    Davson, H &Spaziani, E The Fite of Substances Injected into thd Anterior Chamber of the Eye J Physiol151 202 (1960)PubMedGoogle Scholar
  97. 97.
    DeBeer, E J &Castillo, J C Synthetic Diugs Influencing Neuromuscular Activity An New York Acad Sci54 362 (1951)CrossRefGoogle Scholar
  98. 98.
    DeRoetth, A Jb Ophthalmic Pharmacology and Toxicology A M A Arch Ophth64 292 (1960)Google Scholar
  99. 99.
    DeRoetth, A Jr Ophthalmic Pharmacology and Toxicology A M A Arch Ophth66 277 (1961)Google Scholar
  100. 100.
    Duke-EldeB, S W The Phasic Variations m the Ocular Tension m Primary Glaucoma Am J Ophth35 1 (1952)Google Scholar
  101. 101.
    Ellis, C H, Wnuck, A L, Fanelli, R V, & DeBeer, E Comparative Pharmacological Study of the Mono and Dicholipe Esters of Succinic Acid J Pharmacol109 83 (1953)Google Scholar
  102. 102.
    Foldes, F F, McNall, P G, &BorrIEgo-Hinojosa, J M Succmylchohne A New Approach to Muscular Relaxation m Anesthesiology New England J Med247 596 (1952)Google Scholar
  103. 103.
    Lund, P C Clinical Evaluation of Suclcmyleholme Chloride as a Muscle Relaxant in Anesthesia Am J Surg86 312 (1953)PubMedCrossRefGoogle Scholar
  104. 104.
    Magee, A J Electromyogram of the Extraocular Muscles of the Rabbit in Situ AM A Arch Ophth52 212 (1954)Google Scholar
  105. 105.
    Mather, R W, Schuman, C R, &HaIrbison, S I Influences of Curare and Eserine on Ocular Tension following Electroshoclk Am J Ophth37 859 (1954)PubMedGoogle Scholar
  106. 106.
    Paton, W D M &Zaimis, E Actions and Clinical Assessment of Drugs which Produce Neuromuscular Block Lancet2 508 (1950)Google Scholar
  107. 107.
    Paul, S D &Leopold, I H The Effect of Chlorpromazme on Intraocular Pressure m Experimental Animals Am J Ophth42 107 (1956)Google Scholar
  108. 108.
    Gonzalez, C Topical Fludrocortisonef (9-Alpha-Fluorohydrocortisone) in Ophthalmology Am J Ophth49 619 (1960)PubMedGoogle Scholar
  109. 109.
    Grant, W M Tonography in Chiomc Glaucoma New York J Med56 193 (1956)Google Scholar
  110. 110.
    Griffith, H R &Johnston, G E The Use of Curare in General Anaesthesia Anesthesiology3 418 (1942)Google Scholar
  111. 111.
    Howland, W S, Boyan, C P, &Wife K C The Use of a Steroid (Viadril) as an Anesthetic Agent Anesthesiology17 1 (1956)PubMedCrossRefGoogle Scholar
  112. 112.
    Hunter, A R A Study of a New Relaxant Diug Anaesthesia7 141 (1952)Google Scholar
  113. 113.
    Kennedy, R E Medical Treatment of Chronic Glaucoma New York J Med56 201 (1956)Google Scholar
  114. 114.
    Kirby, D B Use of Curare in Cataract Surgery A M A Arch Ophth43 678 (1950)Google Scholar
  115. 115.
    Kornblueth, W, Jampolsky, A, Tamler, E, &Marg, E Contraction of the Oculorotatory Muscles and Intraocular Pressure A Tonographic and Electromyographic Study of the Effect of Edrophbnium Chloride (Tensilon) and Succmylchohne (Anectme) on the Intraocular Pressure Am J Ophth49 1381 (1900)Google Scholar
  116. 116.
    Landmesse, C M A Study of the 0ronchoconstnctor and Hypotensrve Action of Curanzmg Agents Anesthesiology8 506 (1947)CrossRefGoogle Scholar
  117. 117.
    LinNer, E &Prijot, E Cervical Sympathetic Ganglionectomy and Aqueous Flow A M A Arch Ophth54 831 (1955)PubMedGoogle Scholar
  118. 118.
    Schmerl, E &Stienberg, B Separation of Diencephalic Centers Concerned with Pupillary Motihty and Ocular Tension Am J Ophth33 1379 (1950)Google Scholar
  119. 119.
    Sears, M L &BArAny, E Outflow (Resistance and Adrenergic Mechanisms A M A Arch Ophth64 839 (1960)Google Scholar
  120. 120.
    Stone, H H &Prijot, E Effect of a Barbiturate and Paraldehyde on Aqueous Humour Dynamics in Rabbits A M A Arch Optyth54 834 (1955)Google Scholar
  121. 121.
    Tyner, G S &Scheie, H G Mechanism oi the Myotic-Resistant Pupil with Increased Intraocular Pressure A M A Arch Ophth50 572 (1953)PubMedGoogle Scholar
  122. 122.
    Wistrand, P &Maren, T H The Effect of Carbonic Anhydrase Inhibition on Intraocular Pressure of Rabbits with Diffeient Blood CO2 equilibria Am J Ophth50 291 (1960)PubMedGoogle Scholar
  123. 123.
    Wnuck, A L, Norton, S, &Ellis, C H Controlled Paralysis of Skeletal Muscle Anesthesiology14 367 (1953)PubMedCrossRefGoogle Scholar

Copyright information

© Canadian Anesthesiologists 1965

Authors and Affiliations

  • Arthur S Carballo
    • 1
  1. 1.Department of AnaesthesiaWinnipeg General HospitalUSA

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