Neuroleptanalgesia with fentanyl-droperidol: An appreciation based on more than 1000 anaesthetics for major surgery

  • Ubald Aubry
  • Gaston Carignan
  • Denis Chare-Tee
  • Michael Keeri-Szanto
  • Jean-Paul Lavallee


  1. 1.

    The three-year experience with neuroleptanalgesia in a large teaching hospital is reviewed, and the records of the first thousand such anaesthetics are analysed in detail. The use of this anaesthetic in the supplementation of nitrous-oxide-relaxant anaesthesia is described.

  2. 2.

    In patients such as those studied, NLA appears to have certain quantitative advantages over other agents : better circulation during surgery, reduced incidence of pOStanaesthetic nausea and vomiting, and good patient acceptance. More significantly, the anaesthetic is qualitatively different from other agents in that it makes prolonged postanaesthetic respiratory assistance without tracheotomy feasible.

  3. 3.

    These characteristics amount to specific indication for NLA in certain patients, particularly when major surgery is contemplated. The indications, and some contraindications, are reviewed.



Fentanyl Droperidol Late Recovery Narcotic Antagonist Innovar 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Bien qu’utilisee en Europe depuis 1959, la neuroleptanalgésie (NLA) a été employée en Amérique de facon assez sporadique. Les auteurs ont analysé en détail les résultats de leurs premiers mille cas. Cet agent a été employé avec le protoxyde d’azote et le curare comme adjuvant-la technique d’anesthésie y est décrite.

La NLA semble avoir certains avantages sur les autres agents anesthésiques. Elle permet une meilleure homéostase durant la chirurgie et diminue l’incidence des nausees et vomissements. Cette méthode facilite le maintien de l’assistance respiratoire de façon prolongée en postopératoire, sans avoir recours à la trachéotomie. Nous avons trouvé ici un avantage qualitatif sur les autres agents anesthésiques.

A cause de tous ces facteurs, la NLA a ses indications bien particulières chez certains patients, surtout pour les cas de chirurgie majeure et les mauvais risques. Les indications et quelques contre-indications ont été résumées.


  1. 1.
    Janssen, P. A. Personal communication.Google Scholar
  2. 2.
    Henschel, W. F. Principes et Technique de la Neuroleptanalgesie. Proc. XHIéme Congres français d’anesthesiologie, Bordeaux, 1963.Google Scholar
  3. 3.
    Survey of Anesthesiology 1963-65. Comments by G. F. Marx (7/518), A. R. Hunter (8/352), L. R. Orkin (8/485), and G. M. Wyant (9/64).Google Scholar
  4. 4.
    Aubry, U.;Denis, R.;Keeri-Szanto, M.; &Parent, M. Factors Affecting Survival of the Geriatric Patient after Major Surgery. Canad. Anaesth. Soc. J.12: 510 (1965).PubMedCrossRefGoogle Scholar
  5. 5.
    Corssen, G.;Chodoff, P.;Domino, E. F.; &Kahn, D. R. Neuroleptanalgesia and Anaesthesia for Open-Heart Surgery, Pharmacologic Rationale, and Clinical Experience. J. Thoracic Surg.49: 901 (1965).Google Scholar
  6. 6.
    Cahignan, G.;Keeri-Szanto, M.;Lavallée, J. P.; &LePage, C. Innovar: First Experiences with a New Intravenous Anaesthetic in a Teaching Hospital. Anesth. & Analg. 43:560 (1964).Google Scholar
  7. 7.
    Brown, A. S. Neuroleptanalgesia for the Surgical Treatment of Parkinsonism. Anaesthesia19: 70 (1964).PubMedCrossRefGoogle Scholar
  8. 8.
    Foldes, F. F. Personal communication.Google Scholar
  9. 9.
    Holderness, M. D.;Chase, P. E.; &Dripps, R. D. A Narcotic Analgesic and Rutyro-phenone with Nitrous Oxide for General Anesthesia. Anesthesiology24: 336 (1963).PubMedCrossRefGoogle Scholar
  10. 10.
    Dobkin, A. B. &Lee, P. K. Y. Neuroleptanalgesics: I. Effect of Droperidol, Fentanyl, Innovar, Benzquinamide, and Pentazocaine on the Duration of Thiopental-Induced Sleep in Dogs. Canad. Anaesth. Soc. J.12: 34 (1965).PubMedCrossRefGoogle Scholar
  11. 11.
    Robson, J. C;Davenport, H. T.; &Sugiyama, R. Differentiation of Two Types of Pain by Anesthetics. Anesthesiology26: 31 (1965).PubMedCrossRefGoogle Scholar

Copyright information

© Canadian Anesthesiologists 1966

Authors and Affiliations

  • Ubald Aubry
  • Gaston Carignan
  • Denis Chare-Tee
  • Michael Keeri-Szanto
  • Jean-Paul Lavallee

There are no affiliations available

Personalised recommendations