The American Journal of Digestive Diseases

, Volume 3, Issue 12, pp 906–908 | Cite as

Studies on the chemical nature of the interaction between the intrinsic and extrinsic antianemic factors upon incubation of liver extract and normal gastric juice

  • O. M. Helmer
  • Charles P. Emerson
Experimental Physiology
  • 8 Downloads

Summary

Attempts have been made to determine the chemical change occurring as a result of incubation together of liver extract and normal gastric juice at pH 2.0, 5.6 and 8.0. The chemical constituents of liver extract which were studied were the carboxyl groups, amino nitrogen, and soluble nitrogen after precipitation with trichloracetic acid.

No significant chemical changes were noted in this series of experiments except for those associated with a slight proteolytic effect at pH 2.0, attributable to peptic activity.

Keywords

Gastric Juice Pernicious Anemia Soluble Nitrogen Liver Extract Amino Nitrogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Reimann, F.: Versuche zur Potenzeirung der Wirkung oral verabreichter Leber Kurze wissenschaftliche Mitteilung.Med. Klin., 27:880, 1931.Google Scholar
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    Walden, G. B., and Clowes, G. H. A.: Pernicious Anemia: Method Whereby Therapeutic Efficacy of Liver and Liver Fractions may be Substantially Increased.Proc. Soc. Exper. Biol. and Med., 29:873, 1932.Google Scholar
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    Helmer, O. M., Fouts, Paul J., and Zerfas, L. G.: Increased Potency of Liver Extract by Incubation with Human Gastric Juice.Proc. Soc. Exper. Biol. and Med., 30:775, 1933.Google Scholar
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    VanSlyke, Donald D.: Manometric Determination of Primary Amino Nitrogen and its Application to Blood Analysis.J. Biol. Chem., 83:425, 1929.Google Scholar
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    VanSlyke, Donald D.: Gasometric Micro-Kjeldahl Determination of Nitrogen.J. Biol. Chem., 71:235, 1927.Google Scholar
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    Helmer, O. M., and Fouts, Paul J.: Unpublished data.Google Scholar

Copyright information

© Springer-Verlag 1936

Authors and Affiliations

  • O. M. Helmer
    • 1
  • Charles P. Emerson
    • 1
  1. 1.Indianapolis

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