Factors influencing the effect of radioimmunotherapy on liver cancer
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Factors influencing the therapeutic effect of radioimmunotherapy with131I labeled anti-human hepa tocellular carcinoma (HCC) ferritin antibody (131I-FtAb) on thirty three patients with surgically proven unresectable HCC were studied. Multi-variable analysis with Cox’s regression model revealed that the statistically significant factors include tumor size, activity of131I administered each time and the second-look resection. Survival of patients with tumor diameter less than 10 cm was higher than that of patients with tumor diameter more than 10 cm (1-year survival; 84% versus 50%; 3-year survival; 63% versus 9%). Patients administered with 5.55×108 Bq to 9.25×108 Bq of131I-FtAb each time yielded better effect than those administered with more than 9. 25×108 Bq of131I-FtAb (1-year, survival; 86% ver-sus 55%; 3-year survival; 50% versus 18%). When tumor shrank, patients underwent second-look resection had a higher survival than those without receiving second-look resection (1-year survival; 80% versus 66%; 3-year survival; 80% versus 11%).
KeywordsRadiat Oncol Biol Phys Tumor Diameter Tocellular Carcinoma Single Variable Analysis Multiple Modality Treatment
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