Archives of Pharmacal Research

, Volume 26, Issue 12, pp 1042–1046 | Cite as

Hypocholesterolemic property ofYucca schidigera andQuillaja saponaria extracts in human body

  • Sang-Woo Kim
  • Sang-Kyu Park
  • Sung-ll Kang
  • Han-Chul Kang
  • Han-Jin Oh
  • Chul-Young Bae
  • Dong-Ho Bae


This study was undertaken to observe the effects of the blend of partially purifiedYucca schidigera andQuillaja saponaria extracts on cholesterol levels in the human’s blood and gastrointestinal functions, and to determine if a new cholesterol-lowering drug can be developed by the further purification of the extracts. Ultrafiltration and sequential diafiltration increased the amounts of steroidal saponin in aqueous yucca extract and terpenoid saponin in aqueous qullaja extract from 9.3% and 21.4% to 17.2% and 61.8%, respectively. Taking 0.9 mg of the blend (6:4, v:v) of the resulting filtrates a day for 4 weeks resulted in the decreases in total and LDL cholesterol levels in blood plasma of hyper-cholestrolemic patients with enhancement in gastrointestinal symptoms of patients.

Key words

Yucca schidigera Quillaja saponaria Hypercholesterolemia Saponin 


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  1. Bernardo, R. R., Pinto, A. V., and Parente, J. P., Steroidal saponins from Smilax officinalis.Phytochemistry, 43, 465–469 (1996).PubMedCrossRefGoogle Scholar
  2. Bingham, R., New and effective approaches to the prevention and treatment of arthritis.J. Appl. Nutr., 28, 38–47 (1976).Google Scholar
  3. Choi, J. W., Park, J. H., Lee, W. C., Oh, B. K., Min, J. H., and Lee, W. H., Fluorescence immunoassay of HDL and LDL using protein A LB film.J. Microbiol. Biotechnol., 11, 979–985 (2001).Google Scholar
  4. Chapman, L., Johns, T., and Mahunnah, R. L. A., Saponin-like in vitro characteristics of extracts from selected non-nutrient wild plant food additives used by Masai in meat and milk based soups.Ecol. Food Nutr., 36, 1–22 (1997).Google Scholar
  5. Gee, J. M., Wal, J. M., Miller, K., Atkinson, H., Grigoriadou, F., Wijnands, M. V. W., Penninks, A. H., Wortley, G., and Johnson, I. T., Effects of saponin on the transmucosal passage of (β-lactoglobulin across the proximal small intestine of normal and (β-lactoglobulin-sensitised rats.Toxicol., 117, 219–228 (1997).CrossRefGoogle Scholar
  6. Griminger, P. and Fisher, H., Dietary saponin and plasma cholesterol in the chicken.Proc. Soc. Exp. Biol. Med., 99, 424–426 (1958).PubMedGoogle Scholar
  7. Harwood, H. J., Chandler, C. E., Pellarin, L. D., Bangerter, F. W., Wilkins, R.W., Long, C. A., Cosgrove, P. G., Malinow, M. R., Marzetta, C. A., Pettini, J. L., Savoy, Y. E., and Mayne, J. T., Pharmacologic consequences of cholesterol absorption inhibition: alteration in cholesterol metabolism and reduction in plasma cholesterol concentration induced by the synthetic saponin a-tigogenin cellobioside (CP-88818; tiqueside).J. Lipid Res., 34, 377–395 (1993).PubMedGoogle Scholar
  8. Jenkins, K. J. and Atwal, A. S., Effects of dietary saponins on fecal bile acids and neutral sterols, and availability of vitamins A and E in chick.J. Nutr. Biochem., 5, 134–137 (1994).CrossRefGoogle Scholar
  9. Kensil, C. R., Saponin as vaccine adjuvants.Crit. Rev. Therap. Drug Carrier Syst., 13, 1–55 (1996).Google Scholar
  10. Kensil, C. R., Patel, U., Lennick, M., and Marciani, D., Separation and characterization of saponins with adjuvant activity fro.Quillaja saponaria Molina cortex.J. Immunol., 146, 431–437 (1991).PubMedGoogle Scholar
  11. Koratkar, R. and Rao, A. V., Effects of soya bean saponins in azoxymethane-induced preneoplastic lesions in the colon of mice.Nutr. Cancer, 27, 206–209 (1997).PubMedCrossRefGoogle Scholar
  12. Lindahl, I. L., Shalkop, W. T., Dougherty, R. W., Thompson, C. R., Van Atta, G. R., Bickoff, E. M., Walter, E. D., Livingston, A. G., Guggolz, J., Wilson, R. H., Sideman, M. B., and De, F., Alfalfa saponin. Studies on their chemical, pharmacological, and physical properties in relation to ruminant bloat. USDA Technical Bulletin No. 1161, (1957).Google Scholar
  13. Malinow, M. R., McLaughlin, P., Kohler, G. O., and Livingston, A. L., Prevention of elevated cholesterolemia in monkeys.Steroids, 29, 105–110 (1977).PubMedCrossRefGoogle Scholar
  14. Martin, R. S. and Briones, R., Quality control of commercialquillaja (Quillaja saponaria Molina) extracts by reverse phase HPLC. J. Sci. Food Agric, 80, 2063–2068 (2000).CrossRefGoogle Scholar
  15. Miamki, Y., Nakamura, O., Sashida, Y., Nikaido, T., and Chmoto, T., Steroidal saponins from the bulbs of Triteleia lacteu and their inhibitory activity on cyclic AMP phosphodiesterase.Phytochemistry, 38, 1279–1286 (1995).CrossRefGoogle Scholar
  16. Milgate, J. and Roberts, D. C. K., The nutritional and biological significance of saponins.Nutr. Res., 15, 1223–1249 (1995).CrossRefGoogle Scholar
  17. Nakaue, H. S., Lowry, R. R., Cheeke, P. R., and Arscott, G. H., The effect of varying saponin content on yolk cholesterol level and layer performance.Poult. Sci., 59, 2744–2748 (1980).Google Scholar
  18. Newman, H. A., Kummerow, F. A., and Scott, H. H., Dietary saponin, a factor which may reduce liver and serum cholesterol levels.Poult. Sci., 37, 42–46 (1957).Google Scholar
  19. Oakenfull, D. and Sidhu, G. S., Saponins, In Cheeke, P. R. (ed.). Toxicants of plant origin, vol. 2. CRC Press, Boca Raton, pp. 97–141, (1989).Google Scholar
  20. Olson, M. E., McAllister, T. A., Deselliers, D. W., Cheng, K. J., Buret, A. G., and Ceri, H., Effect of giardiasis on production in a domestic ruminant (lamb) model.Am. J. Vet. Res., 56, 1470–1474 (1996).Google Scholar
  21. Rao, A. V. and Sung, M. K., Saponins as anticarcinogens.J. Nutr., 125, 717s-724s (1995).PubMedGoogle Scholar
  22. Sim, J. S., Kitts, W. D., and Bragg, D. B., Effect of dietary saponin on egg cholesterol level and laying hen performance.Can. J. Anim. Sci., 64, 977–984 (1984).CrossRefGoogle Scholar

Copyright information

© The Pharmaceutical Society of Korea 2003

Authors and Affiliations

  • Sang-Woo Kim
    • 1
  • Sang-Kyu Park
    • 2
  • Sung-ll Kang
    • 2
  • Han-Chul Kang
    • 3
  • Han-Jin Oh
    • 4
  • Chul-Young Bae
    • 5
  • Dong-Ho Bae
    • 6
  1. 1.Division of Endocrinology & Metabolism, Department of MedicineMiz Medi HospitalSeoulKorea
  2. 2.Center for Biomaterials and Biotechnology, Department of Materials Science and EngineeringKwangju Institute of Science and TechnologyKwangjuKorea
  3. 3.Research Center of Celltechs Co.SeoulKorea
  4. 4.Department of Family MedicineSamsung Cheil General Hospital, Sungkyunkwan University of MedicineSeoulKorea
  5. 5.Department of Family MedicineBundang Cha General Hospital, Phochon Jungmoon University of MedicineBundangKorea
  6. 6.Department of Applied Biology & ChemistryKonkuk UniversitySeoulKorea

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