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Archives of Pharmacal Research

, Volume 26, Issue 12, pp 1042–1046 | Cite as

Hypocholesterolemic property ofYucca schidigera andQuillaja saponaria extracts in human body

  • Sang-Woo Kim
  • Sang-Kyu Park
  • Sung-ll Kang
  • Han-Chul Kang
  • Han-Jin Oh
  • Chul-Young Bae
  • Dong-Ho Bae
Article

Abstract

This study was undertaken to observe the effects of the blend of partially purifiedYucca schidigera andQuillaja saponaria extracts on cholesterol levels in the human’s blood and gastrointestinal functions, and to determine if a new cholesterol-lowering drug can be developed by the further purification of the extracts. Ultrafiltration and sequential diafiltration increased the amounts of steroidal saponin in aqueous yucca extract and terpenoid saponin in aqueous qullaja extract from 9.3% and 21.4% to 17.2% and 61.8%, respectively. Taking 0.9 mg of the blend (6:4, v:v) of the resulting filtrates a day for 4 weeks resulted in the decreases in total and LDL cholesterol levels in blood plasma of hyper-cholestrolemic patients with enhancement in gastrointestinal symptoms of patients.

Key words

Yucca schidigera Quillaja saponaria Hypercholesterolemia Saponin 

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Copyright information

© The Pharmaceutical Society of Korea 2003

Authors and Affiliations

  • Sang-Woo Kim
    • 1
  • Sang-Kyu Park
    • 2
  • Sung-ll Kang
    • 2
  • Han-Chul Kang
    • 3
  • Han-Jin Oh
    • 4
  • Chul-Young Bae
    • 5
  • Dong-Ho Bae
    • 6
  1. 1.Division of Endocrinology & Metabolism, Department of MedicineMiz Medi HospitalSeoulKorea
  2. 2.Center for Biomaterials and Biotechnology, Department of Materials Science and EngineeringKwangju Institute of Science and TechnologyKwangjuKorea
  3. 3.Research Center of Celltechs Co.SeoulKorea
  4. 4.Department of Family MedicineSamsung Cheil General Hospital, Sungkyunkwan University of MedicineSeoulKorea
  5. 5.Department of Family MedicineBundang Cha General Hospital, Phochon Jungmoon University of MedicineBundangKorea
  6. 6.Department of Applied Biology & ChemistryKonkuk UniversitySeoulKorea

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