Clinical Reviews in Allergy

, Volume 3, Issue 3, pp 331–349

Food allergens

  • Dean D. Metcalfe


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  1. 1.
    Spies JR: Allergens. J Agri Food Chem 22:30–36, 1974CrossRefGoogle Scholar
  2. 2.
    Berrens L: Atopic allergens in foods. Monogr Allergy 13:164–193, 1971Google Scholar
  3. 3.
    Perlman F: Food allergens, in Catsimpodas N (ed): Immunological Aspects of Foods. Westport, CT, Avi Publishing, 1974, pp 279–316Google Scholar
  4. 4.
    Galant SP: Common food allergens, in Bierman CW, Pearlman DS (eds): Allergic Diseases of Infancy, Childhood, and Adolescence. Philadelphia, WB Saunders, 1980, pp 211–218Google Scholar
  5. 5.
    Bock SA, Lee Y, Remigio LK, May CD: Studies of hypersensitivity reactions to foods in infants and children. J Allergy Clin Immunol 62:327–334, 1978PubMedCrossRefGoogle Scholar
  6. 6.
    Ratner B, Gruehl HL: Passage of native proteins through the normal gastrointestinal wall. J Clin Invest 13:517–532, 1934PubMedCrossRefGoogle Scholar
  7. 7.
    Gray I, Harten M, Walzer M: Studies in mucous membrane hypersensitiveness. IV. The allergic reaction in the passively sensitized mucous membranes of the ileum and colon in humans. Am J Intern Med 13:2050, 1940Google Scholar
  8. 8.
    Sampson H: Role of immediate food hypersensitivity in the pathogenesis of atopic dermatitis. J Allergy Clin Immunol 71:473–480, 1983PubMedCrossRefGoogle Scholar
  9. 9.
    Van Metre TE, Anderson SA, Barnard JH, Bernstein IL, Chaffe FH, Crawford LV, Wittig HJ: A controlled study of the effects on manifestations of chronic asthma of a rigid elimination diet based on Rowe’s cereal-free diet, 1, 2, 3. J Allergy 41:195–208, 1968PubMedCrossRefGoogle Scholar
  10. 10.
    Bock SA, May CD: Adverse reactions to food caused by sensitivity, in Middleton E, Reed CE, Ellis EF (eds): Allergy: Principles and Practice. St. Louis, CV Mosby, 1983, pp 1415Google Scholar
  11. 11.
    Stevenson DD, Simon RA: Sensitivity to ingested metabisulfites in asthmatic subjects. J Allergy Clin Immunol 68:26–32, 1981PubMedCrossRefGoogle Scholar
  12. 12.
    Anderson JA: Introduction, in Anderson JA, Sogn DD (eds): Adverse reactions to foods. American Academy of Allergy and Immunology Committee on Adverse Reactions to Foods. National Institute of Allergy and Infectious Diseases, US Department of Health and Human Services, Public Health Service, National Institutes of Health (in press)Google Scholar
  13. 13.
    Prausnitz C, Kustner H: Studies on hypersensitivity. Centralbl Bakteriol 1:160–169, 1921Google Scholar
  14. 14.
    Aas K: Studies of hypersensitivity to fish. A clinial study. Int Arch Allergy Appl Immunol 29:346–363, 1966PubMedGoogle Scholar
  15. 15.
    Jebsen JW: Electrophoretic and ultracentrifugal study of plaice myogen. Acta Chem Scand 12:1851–1856, 1958CrossRefGoogle Scholar
  16. 16.
    Aas K: Studies of hypersensitivity to fish. Studies of different fractions of extracts from cod muscle tissue. Int Arch Allergy Appl Immunol 31:239–260, 1967PubMedGoogle Scholar
  17. 17.
    Aas K, Jebsen JW: Studies of hypersensitivity to fish. Partial purification and crystallization of a major allergenic component of cod. Int Arch Allergy Appl Immunol 32:1–20, 1967PubMedGoogle Scholar
  18. 18.
    Aas K: Antigens and allergens of fish. Int Arch Allergy Appl Immunol 36:152–155, 1969PubMedGoogle Scholar
  19. 19.
    Elsayed S, Bennich H: The primary structure of allergen M from cod. Scand J Immunol 4:203–208, 1975PubMedCrossRefGoogle Scholar
  20. 20.
    Elsayed S, Ragnarsson U, Netteland B: Solid-phase synthesis of the non-calcium-binding loop of cod allergen M. Scand J Immunol 17:291–295, 1983PubMedCrossRefGoogle Scholar
  21. 21.
    Elsayed S, Sornes S, Apold J, Vik H, Florvaag E: The immunological reactivity of the three homologous repetitive tetrapeptides in the region 41–64 of allergen M from cod. Scand J Immunol 6:77–82, 1982CrossRefGoogle Scholar
  22. 22.
    Hoffman DR, Day ED, Miller JS: The major heat stable allergen of shrimp. Ann Allergy 47:17–22, 1981PubMedGoogle Scholar
  23. 23.
    Fries JH: Peanuts: Allergic and other untoward reactions. Ann Allergy 48:220–226, 1982PubMedGoogle Scholar
  24. 24.
    Barnett D, Baldo BA, Howden ME: Multiplicity of allergens in peanuts. J Allergy Clin Immunol 72:61–68, 1983PubMedCrossRefGoogle Scholar
  25. 25.
    Sachs MI, Jones RT, Yunginger JW: Isolation and partial characterization of a major peanut allergen. J Allergy Clin Immunol 67:27–34, 1981PubMedCrossRefGoogle Scholar
  26. 26.
    Malley A, Baecher L, Madder B, Perlman F: The isolation of allergens from the green pea. J Allergy Clin Immunol 56:282–290, 1975CrossRefGoogle Scholar
  27. 27.
    Malley A, Baecher L, Mackler B, Perlman F: Further characterization of a low-molecular weight allergen fragment isolated from the green pea. Clin Exp Immunol 25:159–164, 1976PubMedGoogle Scholar
  28. 28.
    Shibasaki M, Suzuki S, Tajima S, Nemoto H, Kuroume T: Allergenicity of major component proteins of soybean. Int Arch Allergy Appl Immunol 61:441–448, 1980PubMedGoogle Scholar
  29. 29.
    Moroz LA, Yung WH: Kunitz soybean trypsin inhibitor. N Engl J Med 302:1126–1128, 1980PubMedCrossRefGoogle Scholar
  30. 30.
    Bleumink E, Young E: Studies on the atopic allergen in hen’s egg. I. Identification of the skin reactive fraction in eggwhite. Int Arch Allergy Appl Immunol 35:1–19, 1969PubMedGoogle Scholar
  31. 31.
    Bleumink E, Young E: Studies on the atopic allergen in hen’s egg. II. Further characterization of the skin-reactive fraction in egg-white; immuno-electrophoretic studies. Int Arch Allergy Appl Immunol 40:72–38, 1971PubMedGoogle Scholar
  32. 32.
    Langeland T: A clinical and immunological study of allergy to hen’s egg white. III. Allergens in hen’s egg white studied by crossed radioimmunoelectrophoresis (CRLE). Allergy 37:521–530, 1982PubMedCrossRefGoogle Scholar
  33. 33.
    Hoffman DR: Immunochemical identification of the allergens in egg white. J Allergy Clin Immunol 71:481–486, 1983PubMedCrossRefGoogle Scholar
  34. 34.
    Langeland T, Harbitz O: A clincial and immunological study of allergy to hen’s egg white. V. Purification and identification of a major allergen (antigen 22) in hen’s egg white. Allergy 38:131–139, 1983PubMedCrossRefGoogle Scholar
  35. 35.
    Goldman AS, Sellars WA, Halpern SR, Anderson DW, Furlow TE, Johnson CH Jr: Milk allergy: II. Skin testing of allergic and normal children with purified milk proteins. Pediatrics 32:572–579, 1963PubMedGoogle Scholar
  36. 36.
    Goldman AS, Anderson DW, Sellers WA, Saperstein S, Kniker WT, Halpern SR: I. Oral challenge with milk and isolated milk proteins in allergic children. Pediatrics 32:425–443, 1963PubMedGoogle Scholar
  37. 37.
    Visakorpi JK, Immonen P: Intolerance to cow’s milk and wheat gluten in the primary malabsorption syndrome in infancy. Acta Paediatr Scand 56:49–56, 1967CrossRefGoogle Scholar
  38. 38.
    Kuitunen P, Visakorpi JK, Savilahti E, Pelkonen P: Malabsorption syndrome with cow’s milk intolerance. Arch Dis Child 50:351–362, 1975PubMedCrossRefGoogle Scholar
  39. 39.
    Kletter B, Gery I, Freier S, Noah Z, Davies MA: Immunoglobulin E antibodies to milk proteins. Clin Allergy 1:249–255, 1971CrossRefGoogle Scholar
  40. 40.
    Bleumink E, Young E: Identification of the atopic allergen in cow’s milk. Int Arch Allergy Appl Immunol 34:521–543, 1968PubMedGoogle Scholar
  41. 41.
    Spies JR, Stevan MA, Stein WJ, Coulson EJ: The chemistry of allergens. XX. New antigens generated by pepsin hydrolysis of bovine milk protein. J Allergy 45:208–219, 1970CrossRefGoogle Scholar
  42. 42.
    Haddad ZH, Kalra V, Verma S: IgE antibodies to peptic and peptic-tryptic digests of beta-lactoglobulin: Significance in food hypersensitivity. Ann Allergy 42:368–371, 1979PubMedGoogle Scholar
  43. 43.
    Schwartz HR, Nerurkar LS, Spies JR, Scanlon RT, Bellanti JA: Milk hypersensitivity: RAST studies using new antigens generated by pepsin hydrolysis of beta-lactoglobulin. Ann Allergy 45:242–245, 1980PubMedGoogle Scholar
  44. 44.
    Bleumink E, Berrens L, Young E: Studies on the atopic allergen in ripe tomato fruits. I. Isolation and identification of the allergen. Int Arch Allergy Appl Immunol 30:132–145,1966PubMedGoogle Scholar
  45. 45.
    Bleumink E, Berrens L, Young E: Studies on the atopic allergen in ripe tomato fruits. II. Further chemical characterization of the purified allergen. Int Arch Allergy Appl Immunol 31:25–37, 1967PubMedGoogle Scholar
  46. 46.
    Berrens L: Allergens in seeds. Monogr Allergy 7:74–103, 1971Google Scholar
  47. 47.
    Spies JR, Chambers DC, Coulson EJ: Chemistry of allergens. XII. Ion-exchange fractionation of cottonseed allergen and immunologic properties of the products. Arch Biochem Biophys 84:286–296, 1959PubMedCrossRefGoogle Scholar
  48. 48.
    Gohte CJ, Nilzen A, Holmgren A, Szamosi A, Werner M, Wide L: Medical problems in the detergent industry caused by proteolytic enzymes fromBacillus subtilis. Acta Allergol 27:63–86, 1972Google Scholar
  49. 49.
    Uragoda CG: Tea maker’s asthma. Br J Ind Med 27:181–182, 1970PubMedGoogle Scholar
  50. 50.
    Forsbeck M, Ekenvall L: Respiratory hazards from proteolytic enzymes. Lancet 2:542–525, 1978Google Scholar
  51. 51.
    Hendrick DJ, Davies RJ, Pepys J: Baker’s asthma. Clin Allergy 6:241–250, 1976PubMedCrossRefGoogle Scholar
  52. 52.
    Gohte CJ, Wieslander G, Ancker K, Forsbeck M: Buckwheat allergy: Health food, and inhalation health risk. Allergy 38:155–159, 1983PubMedCrossRefGoogle Scholar
  53. 53.
    Spies JR, Coulson EJ: The chemistry of allergens. VIII. Isolation and properties of an active protein-polysaccharide fraction, CB-1A, from castor beans. J Am Chem Soc 65:1720–1725, 1943CrossRefGoogle Scholar
  54. 54.
    Lehrer SB, Taylor J, Salvaggio JE: Castor bean allergens: Evidence for distinct heat-labile and stable entities. Int Arch Allergy Appl Immunol 65:69–75, 1981PubMedGoogle Scholar
  55. 55.
    Lehrer SB, Karr RM, Salvaggio JE: Analysis of green coffee bean and castor bean allergens using RAST inhibition. Clin Allergy 1:357–366, 1981Google Scholar
  56. 56.
    Blands J, Diamant B, Kallos P, Kallso-Deffner L, Lowenstein H: Flour allergy in bakers. I. Identification of allergenic fractions in flour and comparison of diagnostic methods. Int Arch Allergy Appl Immunol 52:392–406, 1976PubMedGoogle Scholar
  57. 57.
    Baldo BA, Wrigley CW: IgE antibodies to wheat flour components. Clin Allergy 8:109–124, 1978PubMedCrossRefGoogle Scholar
  58. 58.
    Kendall MJ, Schneider R, Cox PS, Hawkins CF: Gluten subtractions in coeliac disease. Lancet 2:1065–1067, 1972PubMedCrossRefGoogle Scholar
  59. 59.
    Ciclitera PJ: Coeliac disease: Current state of the art. Int Med 2:6–9, 1982Google Scholar
  60. 60.
    Frazer AC, Fletcher RF, Ross CAC, Shaw B, Sammons HG, Schneider R: Gluten induced enteropathy. The effect of partially digested gluten. Lancet 2:252–255, 1959PubMedCrossRefGoogle Scholar
  61. 61.
    Dissanayake AS, Truelow SC, Offord RE, Whitehead R: Nature of toxic component of wheat gluten in coeliac disease. Lancet 2:709–712, 1973PubMedCrossRefGoogle Scholar
  62. 62.
    Jos J, Charbonnier L, Mosse J, Olives JP, de Tand MF, Rey J: The toxic fraction of gliadin digests in coeliac disease. Isolation by chromatography on Biogel P-10. Clin Chim Acta 119:263–274, 1982PubMedCrossRefGoogle Scholar
  63. 63.
    Falehuck ZM, Nelson DL, Katz AJ, Bernardin JE, Kasarda DD, Hague NE, Strober W: Gluten-sensitive enteropathy. Influence of histocompatibility type on gluten sensitivity in vitro. J Clin Invest 66:227–233, 1980CrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 1985

Authors and Affiliations

  • Dean D. Metcalfe
    • 1
  1. 1.From the Mast Cell Physiology Section, Laboratory of Clinical InvestigationNational Institute of Allergy and Infectious Diseases, National Institutes of HealthBethesda
  2. 2.National Institutes of HealthBethesda

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