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Itraconazole — a potent antifungal drug

  • Naresh K. Panda
Drug News

Abstract

Itraconazole is an orally active triazole antifungal drug which has demonstrated a broad spectrum of activity and a favourable pharmacokinetic profile. It is a potent inhibitor of most human fungal pathogens including Aspergillus species.

In non comparable clinical trials, Itraconazole was shown to be extremely effective in a wide range of superficial and more serious deep fungal infections when administered once or twice daily. Preliminary findings also indicate that itraconazole, may hold promise for the prophylaxis of opportunistic fungal infections in patients at risk, i.e. women with recurrent vaginal candidiasis, AIDS patients and patients receiving immunosuppressant drugs.

References

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    Hay, R. J., Dupont, B., Garylick, J. R. (1987): First international symposium in itraconazole REv. Inf. dis. 9 (supp). 1–30.Google Scholar
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    Kerkering, T. M., Espinel-lngroff, A. (1987): In vitro synergistic activity of itraconazole and 5-fluorocytosine against Aspergillus fumigatus and aspergillus flavus. In Fromtling, RA (ed). Recent trends in the discovery, development and evaluation of antifungal agents, pp 61–70. JR Prous science publishers. SA.Google Scholar

Copyright information

© Association of Otolaryngologists of India 1997

Authors and Affiliations

  • Naresh K. Panda
    • 1
  1. 1.Department of OtolaryngologyPGIMERChandigarhIndia

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