Medical Oncology

, Volume 12, Issue 4, pp 231–249

Efficacy and toxicity of radiation in preparative regimens for pediatric stem cell transplantation. I: Clinical applications and therapeutic effects

  • Thomas D. Miale
  • Suebsuk Sirithorn
  • Syed Ahmed


Here, we review the role of total body irradiation in the treatment of children with bone marrow transplantation, as well as alternative sources of stem cells. We were unable to demonstrate any clear superiority of TBI-containing preparative regimens, but we were able to find a few definitive reports of significantly enhanced toxicity or important variations in control of the underlying primary diseases, in comparing TBI-based regimens, with those containing only chemotherapy.


bone marrow transplantation busulfan cyclophosphamide pediatrics stem cells total body irradiation 


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Copyright information

© Chapman & Hall 1995

Authors and Affiliations

  • Thomas D. Miale
    • 1
    • 2
    • 4
  • Suebsuk Sirithorn
    • 1
    • 3
  • Syed Ahmed
    • 2
  1. 1.Departments of PediatricsUniversity of Tennessee Medical CenterKnoxville
  2. 2.Departments of Pediatrics Intemal MedicineUniversity of Tennessee Medical CenterKnoxville
  3. 3.Department of PediatricsBhumibol Adulyadej Hospital, R.T.A.F.Bangkhen, BangkokThailand
  4. 4.Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry IIKarolinska InstitutetStockholmSweden

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