Biological Trace Element Research

, Volume 25, Issue 1, pp 79–88

Age-related changes in strontium to calcium ratios in rat tissues

  • Naoko Sugihira
  • Etsuko Kobayashi
  • Kazuo T. Suzuki
Article

DOI: 10.1007/BF02990267

Cite this article as:
Sugihira, N., Kobayashi, E. & Suzuki, K.T. Biol Trace Elem Res (1990) 25: 79. doi:10.1007/BF02990267

Abstract

The Sr/Ca ratios in plasma, urine, bone, and soft tissues for various ages after weaning in male and female rats were determined to examine the effects of aging on the discrimination between strontium (Sr) and calcium (Ca) under physiological conditions. Age-related changes in the Sr/Ca ratios were similar in all tissues; the Sr/Ca ratios decreased rapidly until about 25-wk-old and then slowly, from that period on, reaching much lower values than in the diet. When the logarithm of the Sr/Ca ratio in each tissue was plotted against the logarithm of age, a linear relationship was observed with statistically significant (p<0.05) regression lines. The higher levels of Sr/Ca ratios in all tissues of the younger rats could be explained by the high efficiency of Sr absorption by the small intestine early in life. Parameters for the equations between age and Sr/Ca ratio differed with tissues, suggesting the existence of specific discrimination mechanisms in each tissue.

Index Entries

Strontium calcium discrimination aging, effects of strontium/calcium ratio rat tissues 

Copyright information

© Humana Press Inc. 1990

Authors and Affiliations

  • Naoko Sugihira
    • 1
  • Etsuko Kobayashi
    • 1
  • Kazuo T. Suzuki
    • 1
  1. 1.National Institute for Environmental StudiesTsukuba, IbarakiJapan

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