Biological Trace Element Research

, Volume 15, Issue 1, pp 23–45 | Cite as

The organ distribution of selenium in German adults

  • O. Oster
  • G. Schmiedel
  • W. Prellwitz
Article

Abstract

The selenium concentrations were determined in liver, kidney, skeletal muscle, heart, brain, prostate, testis, bile, lung, and spleen of German traffic accident victims. In addition the nitrogen and phosphorus contents were determined in the same organs and tissues. On a per-weight unit basis, the highest selenium concentration was found in kidney. However, this corresponds to only 4% of the total body selenium. Most of the whole body selenium (50%) is present in skeletal muscle, which thus appears to act as a selenium storage organ. However, there is also evidence that selenium is required for muscle function. In plasma and interstitial fluid, .450 mg of Se, or 7.5% of the total body selenium is present. A comparison of the organ Se concentrations of the German traffic accident victims with the selenium concentrations of the same human organs as reported in different countries indicates that the organ concentrations of West Germans are comparable to that of the population of New Zealand, a low-Se country, and significantly lower than that observed in the organs of American, Canadian, and especially Japanese subjects. The international comparison of the organ selenium concentrations also revealed that the selenium uptake of kidney is higher at low- and adequate dietary Se intakes and lower if the dietary Se supply is high, as is the case for Japanese subjects. Estimates of the daily excretion of selenium with the bile indicate that the amounts are three times higher than the daily urinary losses and in the same order of magnitude as the daily dietary selenium intakes. Enterohepatic reabsorption of selenium from the bile appears to be a significant mechanism of conserving dietary selenium and to maintain Se balance at comparatively low dietary Se intakes.

Index Entries

Selenium concentrations in organs kidney, liver, testis, skeletal muscle, bile, heart, brain, prostate, lung, spleen selenium excretion selenium reabsorption 

References

  1. 1.
    Y. C. Awasthi, C. E. Beutler, and S. K. Srivastava,J. Biol. Chem. 250, 5104 (1975).Google Scholar
  2. 2.
    T. C. Stadtman,Ann. Rev. Biochem. 49, 93, (1980).PubMedCrossRefGoogle Scholar
  3. 3.
    L. Flohé, B. Eisele, and A. Wendel,Hoppe Seyler’s Z. Physiol. Chem. 352, 151 (1971).PubMedGoogle Scholar
  4. 4.
    P. J. O’Brien and A. Little,Can. J. Biochem. 47, 493 (1969).PubMedCrossRefGoogle Scholar
  5. 5.
    O. A. Levander,Fed. Proc. 44, 2579 (1985).PubMedGoogle Scholar
  6. 6.
    K. Schwarz, J. A. Stesney, and C. M. Foltz,Metabolism 8, 88, (1959).PubMedGoogle Scholar
  7. 7.
    G. N. Schrauzer, D. A. White, and C. J. Schneider,Bioinorg. Chem. 6, 265 (1976).PubMedCrossRefGoogle Scholar
  8. 8.
    R. Shamberger and C. Willis,Clin. Lab. Sci. 2, 211 (1971).CrossRefGoogle Scholar
  9. 9.
    W. C. Willet, J. S. Morris, S. Pressel, et al.The Lancet 130 (1983).Google Scholar
  10. 10.
    J. T. Salonen, G. Alfthan, J. K. Huttunen, and P. Puska,Am. J. Epidemiol. 120, 342 (1984).PubMedGoogle Scholar
  11. 11.
    X. Chen, G. Yang, J. Chen, X. Chen, 2. Wen., and K. Ge,Biol. Trace Elem. Res. 2, 91 (1980).CrossRefGoogle Scholar
  12. 12.
    Keshan Disease Research Group of the Chinese Academy of Medical Sciences Peking,Chin. Med. J. 92, 477 (1979).Google Scholar
  13. 13.
    O. Oster, W. Prellwitz, W. Kasper, and T. Meinertz,Clin. Chim. Acta 128, 125 (1983).PubMedCrossRefGoogle Scholar
  14. 14.
    P. J. Collipp and S. Y. Chen,New Engl. J. Med. 304, 1304 (1981).PubMedGoogle Scholar
  15. 15.
    R. A. Johnson, S. S. Baker, J. T. Fallon, et al.,New Engl. J. Med. 304, 1210 (1981).PubMedGoogle Scholar
  16. 16.
    J. T. Salonen and G. Huttunen,Ann. Clin. Res. 18, 30 (1986).PubMedGoogle Scholar
  17. 17.
    O. Oster, W. Drexler, J. Schenk, T. Meinertz, W. Kasper, C. J. Schuster, and W. Prellwitz,Ann. Clin. Res. 18, 36 (1986).PubMedGoogle Scholar
  18. 18.
    O. Oster, W. Prellwitz, C. Luley, T. Meinertz, A. Geibel and W. Kasper,Trace Element Analytical Chemistry in Medicine and Biology, vol. 4, P. Brätter and P. Schramel, Eds., de Gruyter, 1986.Google Scholar
  19. 19.
    J. A. Moore, R. Noiva, and I. C. Wells,Clin. Chem. 307, 1171 (1984).Google Scholar
  20. 20.
    O. Oster and W. Prellwitz,Clin. Chim. Acta 123, 125 (1983).CrossRefGoogle Scholar
  21. 21.
    O. Oster, G. Schmiedel, and W. Prellwitz,Fortschritte in der atomspektrometrischen Spurenanalytik, vol. 2, B. Welz, Ed., VCH Verlagsgesellschaft, 1986.Google Scholar
  22. 22.
    B. Welz, V. Völlkopt and Z. Grobenski,Anal. Chim. Acta, 201 (1982).Google Scholar
  23. 23.
    O. Oster, G. Schmiedel, and W. Prellwitz, 4.Colloquim Atomspektrometrische Spurenanalytik, Konstanz, 1987.Google Scholar
  24. 24.
    G. Schmiedel, Dissertation, Department of Chemistry, University of Mainz, 1986.Google Scholar
  25. 25.
    K. S. Subramanian and J. C. Meranger,Analyst 107, 157 (1982).PubMedCrossRefGoogle Scholar
  26. 26.
    H. A. Schroeder, D. V. Frost, and J. J. Balassa,J. Chron. Dis. 23, 227 (1970).PubMedCrossRefGoogle Scholar
  27. 27.
    C. E. Casey, B. E. Guthrie, M. F. Gaylene, and M. F. Robinson,Arch. Environm. Health 37, 133 (1982).Google Scholar
  28. 28.
    R. E. Burch, M. M. Jetton, H. K. J. Hahn and J. F. Sullivan,Arch. Intern. Med. 139 680 (1979).PubMedCrossRefGoogle Scholar
  29. 29.
    M. Yukawa, K. Amano, M. Suzuki-Yasumoto, and M. Terai,Arch. Environm. Health 35, 36 (1980).Google Scholar
  30. 30.
    IRCP-23: Report of the task group on reference man, Pergamon, London, 1975.Google Scholar
  31. 31.
    O. Oster, G. Schmiedel, and W. Prellwitz,Biol. Trace Element Res., this volume.Google Scholar
  32. 32.
    R. F. Schmidt and G. Thews,Physiologie des Menschen, Springer Verlag, 1985.Google Scholar
  33. 33.
    R. Schelenz,Trace Element Analytical Chemistry in Medicine and Biology, p. 73, P. Brätter and P. Schramel, Eds. de Gruyter, 1984.Google Scholar
  34. 34.
    M. A. Beilstein and P. D. Whanger,J. Nutr. 113, 2138 (1983).PubMedGoogle Scholar
  35. 35.
    D. Behne and Wolters,J. Clin. Chem. Clin. Biochem. 17, 133 (1979).PubMedGoogle Scholar
  36. 36.
    National Research Council—Committee on Dietary Allowances (1980), Recommended Dietary Allowances, 9th ed. Natl. Acad. Sci., Washington, DC.Google Scholar

Copyright information

© Humana Press Inc. 1988

Authors and Affiliations

  • O. Oster
    • 1
  • G. Schmiedel
    • 1
  • W. Prellwitz
    • 1
  1. 1.Department of Clinical ChemistryUniversity Hospital MainzMainzGermany

Personalised recommendations