We report a 38-year-old woman with t(6;9) acute myeloid leukemia who relapsed with localized leukemic cell growth in the bone marrow after she had undergone allogeneic bone marrow transplantation. The localized cell growth was first recognized by an apparent discrepancy in the DEK-CAN fusion transcript levels between the aspirates from the left and right iliac bone marrow. Magnetic resonance imaging of the iliac bone revealed localized cell accumulation in the left side. The nonhomogeneous and localized leukemic cell growth in this case may have been due to the graft-versus-leukemia effect following allogeneic transplantation with donor lymphocyte infusion. Serial monitoring of molecular markers for leukemia at different sites or magnetic resonance imaging of the bone marrow may be of value in detecting this type of relapse.
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Maeda, T., Kosugi, S., Ujiie, H. et al. Localized Relapse in Bone Marrow in a Posttransplantation Patient with t(6;9) Acute Myeloid Leukemia. Int J Hematol 77, 522–525 (2003). https://doi.org/10.1007/BF02986623
- Real-time PCR
- Minimal residual disease
- Acute myeloid leukemia
- Bone marrow transplantation