International Journal of Hematology

, Volume 77, Issue 5, pp 503–511 | Cite as

Pilot Phase I/II Study of New Salvage Therapy (CHASE) for Refractory or Relapsed Malignant Lymphoma

  • Michinori Ogura
  • Yoshitoyo Kagami
  • Hirofumi Taji
  • Ritsuro Suzuki
  • Kazuhisa Miura
  • Takahiro Takeuchi
  • Yasuo Morishima
Article

Abstract

A pilot phase I/II study was conducted as a single-institute trial for evaluation of the feasibility and efficacy of a new salvage chemotherapy, CHASE, for patients with refractory or relapsed lymphoma. The CHASE regimen, consisting of cyclophosphamide, cytosine arabinoside, etoposide, and dexamethasone, was administered every 3 weeks in a maximum of 5 courses. A total of 16 patients were eligible and registered for this study. Myelosuppression was the major toxicity. Although grade 4 leukopenia and grade 3 thrombocytopenia were identified in 15 and 16 patients, respectively, duration of the nadir was brief (median, 3 days). Nonhematological grade 4 toxicity was not observed, and transient elevations of bilirubin and grade 3 aspartate aminotransferase/alanine aminotransferase (AST/ALT) were observed in 2 and 3 courses, respectively, in a total of 57 courses. Complete and partial response rates were 71.4% (10/14) and 7.1% (1/14), respectively. The median percentage of maximal CD34+ cells was 6.1% on day 15, and a median number of 1.88 X 106 CD34+ cells/kg per apheresis were obtained. Thirteen patients received high-dose chemoradiotherapy followed by autologous peripheral blood stem cell transplantation. With a median follow-up time of 36 months from the start of CHASE, the overall survival rate for the 16 patients was 66.6%. These results indicated that CHASE is a safe and effective salvage regimen for malignant lymphoma, has sufficient mobilizing effect on peripheral blood stem cells, and warrants further phase II study.

Key words

CHASE therapy Relapsed lymphoma Salvage chemotherapy PBSC mobilization Auto-PBSCT 

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Copyright information

© The Japanese Society of Hematology 2003

Authors and Affiliations

  • Michinori Ogura
    • 1
  • Yoshitoyo Kagami
    • 1
  • Hirofumi Taji
    • 1
  • Ritsuro Suzuki
    • 1
  • Kazuhisa Miura
    • 1
  • Takahiro Takeuchi
    • 1
  • Yasuo Morishima
    • 1
  1. 1.Department of Hematology and ChemotherapyAichi Cancer Center HospitalAichiJapan

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