Annals of Nuclear Medicine

, 18:35 | Cite as

PET measurements of CBF, OEF, and CMRO2 without arterial sampling in hyperacute ischemic stroke: Method and error analysis

  • Masanobu IbarakiEmail author
  • Eku Shimosegawa
  • Shuichi Miura
  • Kazuhiro Takahashi
  • Hiroshi Ito
  • Iwao Kanno
  • Jun Hatazawa
Original Article


A method for relative measurement of cerebral blood flow (CBF), oxygen extraction fraction (OEF), and metabolic rate of oxygen (CMRO2) using positron emission tomography (PET) without arterial sampling in patients with hyperacute ischemic stroke was presented.


The method requires two PET scans, one for H2 15O injection and one for15O2 inhalation, and calculates regional CBF, CMRO2, and OEF relative to those at the reference brain region by means of table-lookup method. In this study, we calculated “relative lookup-tables” which relate relative CBF to relative H2 15O count, relative CMRO2 to relative15O2 count, and relative OEF to relative15O2/H2 15O count. Two assumptions were applied to the lookup-table calculation: 1) In the reference region, CBF and OEF were assumed to be 50.0 ml/min/100ml and 0.40, respectively, 2) Cerebral blood volume (CBV) was assumed to be constant at 4.0 ml/100ml over the whole brain. Simulation studies were done to estimate the error of the present method derived from the assumptions.


For relative CBF measurements, 20% variation in reference CBF gave about ±10% error for measured relative CBF at maximum. Changes in CBV caused relatively large errors in measured OEF and CMRO2 when relative CBF and OEF decreased. Errors for measured relative OEF caused by 50% variation in CBV were within ±8% at 0.8 of relative CBF and ±12% at 0.4 of relative CBF when relative OEF was greater than 1.0.


CBV effects caused larger errors in estimated OEF and CMRO2 in the region of the ischemie core with decreasing relative CBF and/or OEF but only slight errors in the region of “misery perfusion” with relative OEF values greater than 1.0. The present method makes PET measurements simpler than with the conventional method and increases understanding of the cerebral circulation and oxygen metabolism in patients with hyperacute stroke of several hours after onset.

Key words

PET relative measurement cerebral blood flow oxygen metabolism hyperacute stroke 


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Copyright information

© Springer 2004

Authors and Affiliations

  • Masanobu Ibaraki
    • 1
    Email author
  • Eku Shimosegawa
    • 1
  • Shuichi Miura
    • 1
  • Kazuhiro Takahashi
    • 1
  • Hiroshi Ito
    • 1
  • Iwao Kanno
    • 1
  • Jun Hatazawa
    • 2
  1. 1.Department of Radiology and Nuclear MedicineAkita Research Institute, of Brain and Blood VesselsJapan
  2. 2.Division of Tracer Kinetics and Nuclear MedicineOsaka University Graduate School of MedicineJapan

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