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International Journal of Hematology

, Volume 77, Issue 3, pp 286–294 | Cite as

The Serum Cytokine Profiles of Lymphoma-associated Hemophagocytic Syndrome: A Comparative Analysis of B-Cell and T-Cell/Natural Killer Cell Lymphomas

  • Tatsuharu Ohno
  • Yasunori Ueda
  • Ken-ichi Nagai
  • Takayuki Takahashi
  • Yoshiteru Konaka
  • Teruyuki Takamatsu
  • Takayo Suzuki
  • Masataka Sasada
  • Takashi Uchiyama
Article

Abstract

To elucidate the differences in pathogenesis between lymphoma-associated hemophagocytic syndromes (LAHS) of theT-cell/ natural killer cell (T/NK) and B-cell (B) types,we comparatively analyzed the clinical features and serum cytokine profiles of 33 patients with LAHS registered in the Kyoto University Hematology/Oncology Study Group.The serum cytokine levels of each patient group (B-LAHS versusT/NK-LAHS) were expressed as the ratio of the median to the upper normal values of the respective cytokines and were as follows: 19.05 versus 13.99 for soluble interleukin 2 (IL-2) receptor, 0.67 versus 0.67 for granulocytemacrophage colony-stimulating factor (GM-CSF), 0.64 versus 1.26 for G-CSF, 5.70 versus 3.61 for M-CSF, 1.54 versus 3.39 for interferon γ (IFN-γ), 13.17 versus 1.17 for IL-6, 6.88 versus 1.58 for tumor necrosis factor α (TNF-α), 0.71 versus 0.41 for IL-1, 1.99 versus 0.21 for IL-12, and 105.32 versus 29.65 for IL-10.The serum levels of IL-6,TNF-α, and IL-10 were significantly higher in the B-LAHS group,whereas those of IFN-γ were significantly lower. These differences between the 2 groups may reflect a difference in the pathogenesis. Higher serum levels of IL-6, TNF-α, and IL-10 may be derived at least partly from neoplastic B-cells themselves. In addition, the extremely high serum levels of IL-10 suggest that a compensatory anti-inflammatory process may operate in both groups and give rise to a profound immunosuppressive state and a poor outcome.

Key words

Malignant lymphoma Hemophagocytic syndrome Cytokine Intravascular lymphomatosis Systemic inflammatory response syndrome 

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Copyright information

© The Japanese Society of Hematology 2003

Authors and Affiliations

  • Tatsuharu Ohno
    • 1
  • Yasunori Ueda
    • 2
  • Ken-ichi Nagai
    • 3
  • Takayuki Takahashi
    • 3
  • Yoshiteru Konaka
    • 4
  • Teruyuki Takamatsu
    • 5
  • Takayo Suzuki
    • 6
  • Masataka Sasada
    • 7
  • Takashi Uchiyama
    • 8
  1. 1.Division of Hematology and Immunology, Department of Internal MedicineOhtsu Red Cross HospitalOhtsuJapan
  2. 2.Department of Hematology and OncologyKurashiki Central HospitalKurashiki
  3. 3.Department of Hematology and ImmunologyKobe Central Municipal HospitalKobe
  4. 4.Division of Hematology and Rheumatology, Department of MedicineKitano HospitalOsaka
  5. 5.Department of Hematology and ImmunologyRakuwakai Otowa HospitalKyoto
  6. 6.Department of HematologyShiga Prefectural Center for Adult DiseaseMoriyama
  7. 7.College of Medical TechnologyKyoto UniversityKyoto
  8. 8.Department of Hematology/Oncology, Graduate School of MedicineKyoto UniversityKyotoJapan

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