Immunology of B7-H1 and Its Roles in Human Diseases

  • Hideto Tamura
  • Kiyoyuki Ogata
  • Haidong Dong
  • Lieping Chen
Review Article

Abstract

B7-H1 was originally identified by homology analysis in comparison with B7-1 and B7-2, two molecules with important immunoregulatory functions. B7-H1, however, was broadly induced in the majority of peripheral tissues as well as hematopoietic cells. Upon binding to an as yet unidentified costimulatory receptor on primed T-cells, B7-H1 costimulates T-cell proliferation and preferentially induces interleukin 10 and interferon γ. The costimulatory function of B7-H1 may be critical for enhancing maturation and differentiation of T-cells in lymphoid organs. Conversely, by binding to programmed death 1 receptors on activated T-cells and B-cells, B7-H1 may inhibit ongoing T-cell responses in peripheral tissues by inducing apoptosis and arresting cell-cycle progression. Although a positive regulatory role of B7-H1 has been demonstrated in vitro and in various animal models, a negative regulatory role of B7-H1 has also been documented in human diseases, including cancer, rheumatoid arthritis, and human immunodeficiency virus infection. Delineation of the complex interactions between B7-H1 and its receptors as well as its interplay with other ligands is critical for understanding this new immunoregulatory system. Precise manipulation of B7-H1 and its receptors may provide unique opportunities for designing new disease treatments.

Key words

B7-H1 Costimulation Immunosuppression Tumor Autoimmune diseases 

Copyright information

© The Japanese Society of Hematology 2003

Authors and Affiliations

  • Hideto Tamura
    • 1
  • Kiyoyuki Ogata
    • 1
  • Haidong Dong
    • 2
  • Lieping Chen
    • 2
  1. 1.Third Department of Internal MedicineNippon Medical SchoolBunkyo-ku, TokyoJapan
  2. 2.Department of ImmunologyMayo ClinicRochesterUSA

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