The Journal of Nutrition Health and Aging

, Volume 12, Issue 7, pp 433–450 | Cite as

Sarcopenia: Its assessment, etiology, pathogenesis, consequences and future perspectives

  • Y. Rolland
  • S. Czerwinski
  • G. Abellan van Kan
  • J. E. Morley
  • M. Cesari
  • G. Onder
  • J. Woo
  • R. Baumgartner
  • F. Pillard
  • Y. Boirie
  • W. M. C. Chumlea
  • B. Vellas
Article

Abstract

Sarcopenia is a loss of muscle protein mass and loss of muscle function. It occurs with increasing age, being a major component in the development of frailty. Current knowledge on its assessment, etiology, pathogenesis, consequences and future perspectives are reported in the present review. On-going and future clinical trials on sarcopenia may radically change our preventive and therapeutic approaches of mobility disability in older people.

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Copyright information

© Springer-Verlag France and Serdi Éditions 2008

Authors and Affiliations

  • Y. Rolland
    • 1
    • 2
    • 3
  • S. Czerwinski
    • 4
  • G. Abellan van Kan
    • 3
  • J. E. Morley
    • 5
    • 6
  • M. Cesari
    • 7
  • G. Onder
    • 8
  • J. Woo
    • 9
  • R. Baumgartner
    • 10
  • F. Pillard
    • 11
  • Y. Boirie
    • 12
    • 13
  • W. M. C. Chumlea
    • 4
  • B. Vellas
    • 1
    • 2
    • 3
  1. 1.Inserm, U558ToulouseFrance
  2. 2.University of Toulouse IIIToulouseFrance
  3. 3.Department of Geriatric MedicineCHU ToulouseToulouseFrance
  4. 4.Department of Community Health, Lifespan Health Research Center, Boonshoft School of MedicineWright State University Dayton
  5. 5.Geriatric Research, Education and Clinical CenterSt Louis
  6. 6.Medical Center, and Division of Geriatric MedicineSaint Louis UniversitySt LouisUSA
  7. 7.Department of Aging and Geriatric ResearchUniversity of Florida - Institute on AgingGainesville
  8. 8.Department of Gerontological, Geriatric and Physiatric SciencesCatholic University of Sacred HeartRomeItaly
  9. 9.Division of geriatrics, Department of Medicine and Therapeutics. The Prince of Wales HospitalChinese University of Hong-KongChina
  10. 10.Department of Epidemiology and Population Health, School of Public Health and Information SciencesUniversity of LouisvilleLouisville
  11. 11.Service d’Exploration de la Fonction Respiratoire et de Medecine du SportHôpital LarreyToulouse Cedex 9
  12. 12.UFR Médecine, UMR1019, Unité Nutrition HumaineUniversity Clermont 1France
  13. 13.Clinical Nutrition UnitCHU Clermont-FerrandFrance

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