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Vascular risk factors, alcohol intake, and cognitive decline

  • F. Panza
  • C. Capurso
  • A. D’Introno
  • A. M. Colacicco
  • V. Frisardi
  • A. Santamato
  • M. Ranieri
  • P. Fiore
  • G. Vendemiale
  • D. Seripa
  • A. Pilotto
  • A. Capurso
  • V. Solfrizzi
Clinical Neurosciences

Abstract

Since the therapeutic options currently available have demonstrated limited efficacy, the search for preventive strategies for cognitive decline and dementia is mandatory. A possible role of vascular and lifestyle-related factors was recently proposed for age-related changes of cognitive function, predementia syndromes, and cognitive decline of degenerative (Alzheimer’s disease, AD) or vascular origin. At present, cumulative evidence suggested that vascular risk factors may be important in the development of mild cognitive impairment (MCI), dementia, and AD. Among vascular-related factors, metabolic syndrome has been associated with the risk of cognitive decline and overall dementia. Moderate alcohol drinking has been proposed as a protective factor against MCI and dementia in several longitudinal studies, but contrasting findings also exist. However, in most cases, these were only observational studies, and results are awaited from large multicenter randomized clinical trials in older persons. At present, vascular risk factor management, lifestyle changes, and drugs could be employed together to delay the onset of dementia syndromes.

Key words

Alcohol metabolic syndrome vascular risk factors predementia syndromes dementia Alzheimer’s disease vascular dementia mild cognitive impairment 

References

  1. 1.
    Solfrizzi V; Capurso C; D’Introno A; Colacicco AM; Santamato A; Ranieri M; Fiore P; Capurso A; Panza F. Lifestyle-related factors in predementia and dementia syndromes. Expert Rev Neurother 2008;8: 133–158.PubMedCrossRefGoogle Scholar
  2. 2.
    Solfrizzi V; Panza F; Colacicco AM; D’Introno A; Capurso C; Torres F; Grigoletto F; Maggi S; Del Parigi A; Reiman EM; Caselli RJ; Scafato E; Farchi G; Capurso A; Italian Longitudinal Study on Aging Working Group.Vascular risk factors; incidence of MCI; and rates of progression to dementia. Neurology 2004;63: 1882–1891.PubMedGoogle Scholar
  3. 3.
    Panza F; D’Introno A; Colacicco AM; Capurso C; Parigi AD; Capurso SA; Caselli RJ; Pilotto A; Scafato E; Capurso A; Solfrizzi V. Cognitive frailty: Predementia syndrome and vascular risk factors. Neurobiol Aging 2006;27: 933–940.PubMedCrossRefGoogle Scholar
  4. 4.
    Panza F; D’Introno A; Colacicco AM; Basile AM; Capurso C; Kehoe PG; Capurso A; Solfrizzi V. Vascular risk and genetics of sporadic late-onset Alzheimer’s disease. J Neural Transm 2004; 111: 69–89.PubMedCrossRefGoogle Scholar
  5. 5.
    Kivipelto M; Helkala EL; Hänninen T; Laakso MP; Hallikainen M; Alhainen K; Soininen H; Tuomilehto J; Nissinen A. Midlife vascular risk factors and Alzheimer’s disease in later life: longitudinal; population based study. BMJ 2001; 322: 1447–1451.PubMedCrossRefGoogle Scholar
  6. 6.
    Lopez OL; Jagust WJ; Dulberg C; Becker JT; DeKosky ST; Fitzpatrick A; Breitner J; Lyketsos C; Jones B; Kawas C; Carlson M; Kuller LH. Risk factors for mild cognitive impairment in the cardiovascular health study cognition study. Part 2. Arch Neurol 2003;60: 1394–139.PubMedCrossRefGoogle Scholar
  7. 7.
    DeCarli C; Mungas D; Harvey D; Reed B; Weiner M; Chui H; Jagust W. Memory impairment; but not cerebrovascular disease; predicts progression of MCI to dementia. Neurology 2004;63: 220–227.PubMedGoogle Scholar
  8. 8.
    Panza F; Capurso C; Solfrizzi V. Cardiovascular factors and cognitive impairment: a role for unsaturated fatty acids and mediterranean diet? Am J Cardiol 2006;98: 1120–1121.PubMedCrossRefGoogle Scholar
  9. 9.
    Kivipelto M; Ngandu T; Laatikainen T; Winblad B; Soininen H; Tuomilehto J. Risk Score for prediction of dementia risk in 20 years among middle aged people: a longitudinal population based study. Lancet Neurology 2006;9: 735–741.CrossRefGoogle Scholar
  10. 10.
    Kivipelto M; Solomon A. Alzheimer’s disease — the ways of prevention. J Nutr Health Aging 2008; 12: 89S-94S.PubMedCrossRefGoogle Scholar
  11. 12.
    Avogaro P; Crepaldi G; Enzi G; Tiengo A. Association of hyperlipemia; diabetes mellitus and mild obesity. Acta Diabetol Lat 1967; 4: 572–590.CrossRefGoogle Scholar
  12. 13.
    Kahn R; Buse J; Ferrannini E; Stern M; American Diabetes Association; European Association for the Study of Diabetes. The metabolic syndrome: time for a critical appraisal—joint statement from the American Diabetes Association and the European association for the Study of Diabetes. Diabetes Care 2005;28: 2289–2304.PubMedCrossRefGoogle Scholar
  13. 14.
    Lakka HM; Laaksonen DE; Lakka TA; Niskanen LK; Kumpusalo E; Tuomilehto J; Salonen JT. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 2002; 288: 2709–2716.PubMedCrossRefGoogle Scholar
  14. 15.
    Hyung-Min K; Kim BJ. Metabolic syndrome as an independent risk factor of silent brain infarction in healthy people. Stroke 2006; 37: 466–472.CrossRefGoogle Scholar
  15. 16.
    Wang J; Ruotsalainen S; Moilanen L; Lepistö P; Laakso M; Kuusisto J. The metabolic syndrome predicts incident stroke: a 14-year follow-up study in elderly people in Finland. Stroke 2008;39: 1078–1083.PubMedCrossRefGoogle Scholar
  16. 17.
    Yaffe K. Metabolic syndrome and cognitive disorders: is the sum greater than its parts? Alzheimer Dis Assoc Disord 2007;21: 167–171PubMedCrossRefGoogle Scholar
  17. 18.
    Yaffe K; Kanaya A; Lindquist K; Simonsick EM; Harris T; Shorr RI; Tylavsky FA; Newman AB. The metabolic syndrome; inflammation; and risk of cognitive decline. JAMA 2004;292: 2237–2242.PubMedCrossRefGoogle Scholar
  18. 19.
    Yaffe K; Haan M; Blackwell T; Cherkasova E; Whitmer RA; West N. Metabolic syndrome and cognitive decline in elderly Latinos: findings from the Sacramento Area Latino Study of Aging study. J Am Geriatr Soc 2007;55: 758–762.PubMedCrossRefGoogle Scholar
  19. 20.
    Dik MG; Jonker C; Comijs HC; Deeg DJ; Kok A; Yaffe K; Penninx BW. Contribution of metabolic syndrome components to cognition in older individuals. Diabetes Care 2007;30: 2655–2660.PubMedCrossRefGoogle Scholar
  20. 21.
    Komulainen P; Lakka TA; Kivipelto M; Hassinen M; Helkala EL; Haapala I; Nissinen A; Rauramaa R. Metabolic syndrome and cognitive function: a population-based follow-up study in elderly women. Dement Geriatr Cogn Disord 2007;23: 29–34.PubMedCrossRefGoogle Scholar
  21. 22.
    Kalmijn S; Foley D; White L; Burchfiel CM; Curb JD; Petrovitch H; Ross GW; Havlik RJ; Launer LJ. Metabolic cardiovascular syndrome and risk of dementia in Japanese-American elderly men: the Honolulu-Asia aging study. Arterioscler Thromb Vasc Biol 2000;20: 2255–2260.PubMedGoogle Scholar
  22. 23.
    Vanhanen M; Koivisto K; Moilanen L; Helkala EL; Hänninen T; Soininen H; Kervinen K; Kesäniemi YA; Laakso M; Kuusisto J. Association of metabolic syndrome with Alzheimer disease: a population-based study. Neurology 2006;67: 843–847.PubMedCrossRefGoogle Scholar
  23. 24.
    Razay G; Vreugdenhil A; Wilcock G. The metabolic syndrome and Alzheimer disease. Arch Neurol 2007;64: 93–96.PubMedCrossRefGoogle Scholar
  24. 25.
    Roriz-Cruz M; Rosset I; Wada T; Sakagami T; Ishine M; De Sá Roriz-Filho J; Cruz TR; Hosscinkhani M; Rodrigues RP; Sudoh S; Arai H; Wakatsuki Y; Souza AC; Nakagawa M; Kita T; Matsubayashi K. Cognitive impairment and frontal-subcortical geriatric syndrome are associated with metabolic syndrome in a stroke-free population. Neurobiol Aging 2007;28: 1723–36.PubMedCrossRefGoogle Scholar
  25. 26.
    van den Berg E; Biessels GJ; de Craen AJ; Gussekloo J; Westendorp RG. The metabolic syndrome is associated with decelerated cognitive decline in the oldest old. Neurology 2007;69: 979–985.PubMedCrossRefGoogle Scholar
  26. 27.
    Maggi S; Noale M; Zambon A; Limongi F; Romanato G; Crepaldi G; ILSA Working Group.Validity of the ATP III diagnostic criteria for the metabolic syndrome in an elderly Italian Caucasian population The Italian Longitudinal Study on Aging. Atherosclerosis 2007; doi:10.1016/j.atherosclerosis.2007.08.002.Google Scholar
  27. 28.
    Pugh KG; Lipsitz LA. The microvascular frontal-subcortical syndrome of aging. Neurobiol Aging 2002;23: 421–431.PubMedCrossRefGoogle Scholar
  28. 29.
    Launer LJ; Feskens EJ; Kalmijn S; Kromhout D. Smoking; drinking; and thinking. The Zutphen Elderly Study. Am J Epidemiol 1996; 143: 219–227.PubMedGoogle Scholar
  29. 30.
    Elias PK; Elias MF; D’Agostino RB; Silbershatz H; Wolf PA. Alcohol consumption and cognitive performance in the Framingham Heart Study; Am J Epidemiol 1999; 150: 580–589.PubMedGoogle Scholar
  30. 31.
    Galanis DJ; Joseph C; Masaki KH; Petrovich H; Ross GW; White L. A longitudinal study of drinking and cognitive performance in elderly Japanese American men: the Honolulu-Asia aging study. Am J Public Health 2000;90: 1254–1259.PubMedCrossRefGoogle Scholar
  31. 32.
    Leroi I; Sheppard JM; Lyketsos CG. Cognitive function after 11.5 years of alcohol use: relation to alcohol use. Am J Epidemiol 2002; 156: 747–752.PubMedCrossRefGoogle Scholar
  32. 33.
    Orgogozo JM; Dartigues JF; Lafont S; Letenneur L; Commenges D; Salamon R; Renaud S; Breteler MB. Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area. Rev Neurol (Paris) 1997;153: 185–192.Google Scholar
  33. 34.
    Ruitenberg A; van Swieten JC; Witteman JC; Mehta KM; van Duijn CM; Hofman A; Breteler MM. Alcohol consumption and risk of dementia: the Rotterdam Study. Lancet 2002;359: 281–186.PubMedCrossRefGoogle Scholar
  34. 35.
    Mukamal KJ; Kuller LH; Fitzpatrick AL; Longstreth WT Jr; Mittleman MA; Siscovick DS. Prospective study of alcohol consumption and risk of dementia in older adults. JAMA 2003; 289: 1405–1413.PubMedCrossRefGoogle Scholar
  35. 36.
    Truelsen T; Thudium D; Grønbæk M. Amount and type of alcohol and risk of dementia: the Copenhagen city heart study. Neurology 2002;59: 1313–1319.PubMedGoogle Scholar
  36. 37.
    Dufouil C; Tzourio C; Brayne C; Berr C; Amouyel P; Alperovitch A. Influence of apolipoprotein E genotype on the risk of cognitive deterioration in moderate drinkers and smokers. Epidemiology 2000; 11: 280–284.PubMedCrossRefGoogle Scholar
  37. 38.
    Luchsinger JA; Tang MX; Siddiqui M; Shea S; Mayeux R. Alcohol intake and risk of dementia. J. Am. Geriatr. Soc. 2004;52: 540–546.PubMedCrossRefGoogle Scholar
  38. 39.
    Mehlig K; Skoog I; Guo X; Schütze M; Gustafson D; Waern M; Ostling S; Björkelund C; Lissner L. Alcoholic beverages and incidence of dementia: 34-year follow-up of the prospective population study of women in Göteborg. Am J Epidemiol 2008; 167: 684–691.PubMedCrossRefGoogle Scholar
  39. 40.
    Solfrizzi V; D’Introno A; Colacicco AM; Capurso C; Del Parigi A; Baldassarre G; Scapicchio P; Scafato E; Amodio M; Capurso A; Panza F; Italian Longitudinal Study on Aging Working Group. Alcohol consumption; mild cognitive impairment; and progression to dementia. Neurology 2007;68: 1790–1789.PubMedCrossRefGoogle Scholar
  40. 41.
    Anttila T; Helkala EL; Viitanen M; Kåreholt I; Fratiglioni L; Winblad B; Soininen H; Tuomilehto J; Nissinen A; Kivipelto M. Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study. BMJ 2004;329: 539.PubMedCrossRefGoogle Scholar
  41. 42.
    Espeland MA; Gu L; Masaki KH; Langer RD; Coker LH; Stefanick ML; Ockene J; Rapp SR. Association between reported alcohol intake and cognition: results from the Women’s Health Initiative Memory Study. Am J Epidemiol 2005; 161: 228–238.PubMedCrossRefGoogle Scholar
  42. 43.
    Palomaki H; Kaste M. Regular light-to-moderate intake of alcohol and the risk of ischémic stroke: is there a beneficial effect? Stroke 1993;24: 1828–1832.PubMedGoogle Scholar
  43. 44.
    den Heijer T; Vermeer SE; van Dijk EJ; Prins ND; Koudstaal PJ; van Duijn CM; Hofman A; Breteler MM. Alcohol intake in relation to brain magnetic resonance imaging findings in older persons without dementia. Am J Clin Nutr 2004;80: 992–997.Google Scholar
  44. 45.
    Gaziano JM; Buring JE; Breslow JL; Goldhaber SZ; Rosner B; VanDenburgh M; Willett W; Hennekens CH. Moderate alcohol intake; increased levels of high-density lipoprotein and its subfractions; and decreased risk of myocardial infarction. N Engl J Med 1993;329: 1829–1834.PubMedCrossRefGoogle Scholar
  45. 46.
    Camargo CA Jr; Williams PT; Vranizan KM; Albers JJ; Wood PD. The effect of moderate alcohol intake on serum apolipoproteins A-I and A-II. A controlled study. JAMA 1985;253: 2854–2857.PubMedCrossRefGoogle Scholar
  46. 47.
    Howard A; Chopra M; Thurnham D; Strain J; Fuhrman B; Aviram M. Red wine consumption and inhibition of LDL oxidation: what are the important components? Med Hypotheses 2002;59: 101–104.PubMedCrossRefGoogle Scholar
  47. 48.
    Bertelli AA; Migliori M; Panichi V; Longoni B; Origlia N; Ferretti A; Cuttano MG; Giovannini L. Oxidative stress and inflammatory reaction modulation by white wine. Ann N Y Acad Sci 2002; 957: 295–301.PubMedGoogle Scholar
  48. 49.
    Serafini M; Maiani G; Ferro-Luzzi A. Alcohol-free red wine enhances plasma antioxidant capacity in humans. J Nutr 1998; 128: 1003–1007.PubMedGoogle Scholar
  49. 50.
    Heinonen FM; Lehtonen PJ; Hopia AI. Antioxidant activity of berry and fruit wines and liquors. J Agric Food Chem 1998;46: 25–31.PubMedCrossRefGoogle Scholar
  50. 51.
    DeKosky ST. Statin therapy in the treatment of Alzheimer disease: what is the rationale? Am J Med 2005;118(Suppl 12A): 48–53.PubMedCrossRefGoogle Scholar
  51. 52.
    Korczyn AD; Vakhapova V. The prevention of the dementia epidemic. J Neurol Sci 2007;257: 2–4.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag France and Serdi Éditions 2008

Authors and Affiliations

  • F. Panza
    • 1
  • C. Capurso
    • 2
  • A. D’Introno
    • 1
  • A. M. Colacicco
    • 1
  • V. Frisardi
    • 1
  • A. Santamato
    • 3
  • M. Ranieri
    • 4
  • P. Fiore
    • 3
  • G. Vendemiale
    • 2
  • D. Seripa
    • 5
  • A. Pilotto
    • 6
  • A. Capurso
    • 1
  • V. Solfrizzi
    • 1
  1. 1.Department of Geriatrics, Center for Aging Brain, Memory UnitUniversity of Bari, PoliclinicoBariItaly
  2. 2.Department of GeriatricsUniversity of FoggiaFoggiaItaly
  3. 3.Department of Physical Medicine and RehabilitationUniversity of FoggiaFoggiaItaly
  4. 4.Department of Neurological and Psychiatric SciencesUniversity of BariBariItaly
  5. 5.Laboratory of Gerontology & Geriatrics, Department of ResearchIRCCS Casa Sollievo della SofferenzaSan Giovanni Rotondo (FG)Italy
  6. 6.Geriatric Unit, Department of Medical SciencesIRCCS Casa Sollievo della SofferenzaSan Giovanni Rotondo (FG)Italy

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