International Journal of Hematology

, Volume 74, Issue 3, pp 252–257 | Cite as

RUNX1/AML1: A Central Player in Hematopoiesis

  • Tsukasa Okuda
  • Motohiro Nishimura
  • Mitsushige Nakao
  • Yasuko Fujitaa
Progress in hematology

Abstract

It has been well established that a number of transcription factors play critical roles in regulating the fate of hematopoietic stem cell populations. One of them is the leukemia-associated transcription factor acute myeloid leukemia 1 (AML1; also known as runt-related transcription factor 1, or RUNX1). This gene was originally cloned from the breakpoint of the t(8;21) reciprocal chromosome translocation and was later recognized as one of the most frequent targets of leukemia-associated gene aberrations. Gene-targeting experiments revealed that transcriptionally active AML1 is essential for the establishment of definitive hematopoiesis. More specifically, this gene functions in the emergence of the hematopoietic progenitor cells from the hemogenic endothelium by budding in the aorta-gonad-mesonephros region, and its expression points to the sites with strong potential for the emergence of hematopoietic stem cells. This review discusses aspects of the biologic properties of AML1 in early hematopoietic development.

Key words

RUNX1 AML1 Hematopoiesis AGM region Hemogenic endothelium 

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Copyright information

© The Japanese Society of Hematology 2001

Authors and Affiliations

  • Tsukasa Okuda
    • 1
  • Motohiro Nishimura
    • 1
    • 2
  • Mitsushige Nakao
    • 1
    • 3
  • Yasuko Fujitaa
    • 1
    • 3
  1. 1.Departments of HygieneKyoto Prefectural University of MedicineKyotoJapan
  2. 2.Departments of Thoracic SurgeryKyoto Prefectural University of MedicineKyotoJapan
  3. 3.Departments of Internal MedicineKyoto Prefectural University of MedicineKyotoJapan

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