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International Journal of Hematology

, Volume 73, Issue 2, pp 137–144 | Cite as

Pathogenesis of Thrombosis in Patients with Malignancy

  • Anna Falanga
  • Maria Benedetta Donati
Progress in hematology

Abstract

Cancer cells can contribute to activation of the clotting system by their capacity to produce and release procoagulant/fibrinolytic substances and inflammatory cytokines, and by their interaction with host cells (endothelial, monocytes, platelets, and neutrophils). Moreover, anticancer drugs (chemotherapy/hormone therapy) may greatly affect the risk of thromboembolic complications in cancer patients by similar mechanisms, eg, through the release of procoagulants by tumor cells, through endothelial damage, or stimulation of tissue factor production by host cells. The interactions between cancer/metastatic processes and thrombosis have been reviewed here from the pathogenetic viewpoint. We hope that better knowledge of these pathogenetic pathways will lead to the development of more targeted strategies to prevent thromboembolism in cancer patients.

Key words

Thrombosis Cancer Metastasis Tumor procoagulants Cancer chemotherapy 

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Copyright information

© The Japanese Society of Hematology 2001

Authors and Affiliations

  1. 1.Hematology DivisionOspedali RiunitiBergamo
  2. 2.Department of Vascular Medicine and PharmacologyIstituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri SudSanta Maria ImbaroItaly

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