International Journal of Hematology

, Volume 73, Issue 1, pp 84–86

Elevated serum-soluble fas ligand in Histiocytic necrotizing lymphadenitis

  • Kei Kato
  • Koichi Ohshima
  • Keizo Anzai
  • Junji Suzumiya
  • Masahiro Kikuchia
Review Article

Abstract

Recent studies have indicated that Fas and perforin-based mechanisms seem to induce apoptosis in histiocytic necrotizing lymphadenitis (HNL). In this study, we evaluated the serum levels of soluble Fas ligand (sFasL) in 30 HNL patients using paired sera. Elevations in sFasL levels were detected in 9 patients in the active stage. In the convalescent stage, the levels of sFasL decreased to an undetectable degree after 2 weeks.These findings indicate the possibility that sFasL plays an important role in the constitutional symptoms and pathogenesis of HNL and, furthermore, that it can act as a surrogate marker of the disease activity.

Key words

Histiocytic necrotizing lymphadenitis Fas ligand Soluble Fas ligand Perforin Apoptosis 

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Copyright information

© The Japanese Society of Hematology 2001

Authors and Affiliations

  • Kei Kato
    • 1
  • Koichi Ohshima
    • 1
  • Keizo Anzai
    • 2
  • Junji Suzumiya
    • 1
  • Masahiro Kikuchia
    • 1
  1. 1.First Department of PathologySchool of Medicine, Fukuoka UniversityJapan
  2. 2.Department of Laboratory MedicineSchool of Medicine, Fukuoka UniversityJapan
  3. 3.Department of Pathology, School of MedicineFukuoka UniversityJonan-KuJapan

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