Effect of diethylstilbestrol concentration and duration of contact with nursing Levant voles, on the reproduction of their female offspring
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Abstract
A 5-minute contact of nursing mothers of the Levant vole,Microtus guentheri, with paper impregnated with a DES suspension in soybean oil (125 μg/cm2 ) caused sterilization of 60% of the newborn female offspring. A 1-hour contact was sufficient to sterilize more than 90% of them. When the DES concentration was decreased to 1 μg/cm2 only 44% of the newborn female offspring were sterile although their nursing mothers had been exposed to contact with the treated paper for a period of 2 hours. The concentration of 0.1 μg/cm2 was totally ineffective in causing sterilization. Treatment of nesting material with DES offers a promising means of reproductive suppression in Levant voles.
Key Words
Microtus guentheir diethylstilbestrol (DES) chemosterilization contact sterilization sterility diagnosis DES contact of mothers sterilizes female offspringPreview
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