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Archives of Pharmacal Research

, Volume 27, Issue 7, pp 790–796 | Cite as

Wild ginseng prevents the onset of high-fat diet induced hyperglycemia and obesity in icr mice

  • Se Na Yun
  • Sang Jung Moon
  • Sung Kwon Ko
  • Byung Ok Im
  • Sung Hyun Chung
Research Articles Articles

Abstract

Ginseng is a shade-loving perennial herb that is cultivated mainly in Korea, Japan, and China. The ginseng root has been used as a tonic remedy, and its antidiabetic activity has been demonstrated as early as 1920s. Although wild ginseng was anecdotally thought to be superior to cultivated ginseng as far as pharmacological properties were concerned, there have been no prior reports on the antidiabetic effect of wild ginseng. In this study, we investigated the preventative anti-diabetic and anti-obese effects of wild ginseng ethanol extract (WGEE). In the preventive experiment, WGEE co-administered with a high fat diet significantly inhibited body weight gain, fasting blood glucose, triglyceride, and free fatty acid levels in a dose dependent manner. WGEE-treated mice at doses of 250 and 500 mg/kg improved the insulin resistance index by 55% and 61% compared to the high fat diet (HFD) control, respectively. Diameters of white and brown adipocytes were also decreased by 62% and 46% in the WG500-treated group compared to those in HFD fed control mice. Taken together, WGEE has potential as a preventive agent for type 2 diabetes mellitus (and possibly obesity) and deserves clinical trial in the near future.

Key words

Wild ginseng ethanol extract Anti-diabetic effect Anti-obese effect High fat diet Insulin resistance index 

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Copyright information

© The Pharmaceutical Society of Korea 2004

Authors and Affiliations

  • Se Na Yun
    • 1
  • Sang Jung Moon
    • 2
  • Sung Kwon Ko
    • 3
  • Byung Ok Im
    • 3
  • Sung Hyun Chung
    • 1
  1. 1.Laboratory of Pharmacology and Clinical Pharmacy, School of PharmacyKyung Hee UniversitySeoulKorea
  2. 2.Sansam Nara CorpSeoulKorea
  3. 3.Korea Ginseng InstituteChung-Ang UniversityAnsungKorea

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