Effects of polysaccharide ginsan fromPanax ginseng on liver function

  • Jie-Young Song
  • Medea Akhalaia
  • Alexander Platonov
  • Hyung-Doo Kim
  • In-Sung Jung
  • Young-Soo Han
  • Yeon-Sook Yun
Reasearch Articles Articles

DOI: 10.1007/BF02980127

Cite this article as:
Song, JY., Akhalaia, M., Platonov, A. et al. Arch Pharm Res (2004) 27: 531. doi:10.1007/BF02980127

Abstract

Ginsan, a polysaccharide isolated fromPanax ginseng, has been shown to be a potent immunomodulator, producing a variety of cytokines such as TNF-α, IL-1β IL-2, IL-6, IL-12, IFN-γ and GM-CSF, and stimulating lymphoid cells to proliferate. In the present study, we analyzed some immune functions 1st-5th days after ginsan i.p. injection, including the level of non-protein thiols (NPSH) as antioxidants, heme oxygenase (HO) activity as a marker of oxidative stress, zoxazolamine-induced paralysis time and level of hepatic cytochrome P-450 (CYP450) as indices of drug metabolism system, and activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin, and albumin level as indicators of hepatotoxicity. Ginsan in the dose of 100 mg/kg caused marked elevation (1.7~2 fold) of HO activity, decrease of total CYP450 level (by 20-34%), and prolongation of zoxazolamine induced paralysis time (by 65-70%), and showed some differences between male and female mice. Ginsan treatment did not seem to cause hepatic injury, since serum AST, ALT, and ALP activities and levels of total bilirubin and albumin were not changed.

Key words

Ginsan Polysaccharide Non-protein thiols Cytochrome P450 Heme oxygenase 

Copyright information

© The Pharmaceutical Society of Korea 2004

Authors and Affiliations

  • Jie-Young Song
    • 1
  • Medea Akhalaia
    • 2
  • Alexander Platonov
    • 3
  • Hyung-Doo Kim
    • 1
  • In-Sung Jung
    • 1
  • Young-Soo Han
    • 1
  • Yeon-Sook Yun
    • 1
  1. 1.Laboratory of ImmunologyKorea Institute of Radiological & Medical Sciences, KAERISeoulKorea
  2. 2.Laboratory of Radiation Biophysics, Department of BiophysicsMoscow State UniversityVorobiovi GoryRussia
  3. 3.Department of Radioecology Ecological FacultyPeoples Friendship University of RussiaMoscowRussia

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