Archives of Pharmacal Research

, Volume 27, Issue 2, pp 184–188 | Cite as

Antioxidant activities of isoflavones from the rhizomes ofbelamcanda chinensis on carbon tetrachloride-lnduced hepatic injury in rats

  • Sang Hoon Jung
  • Yeon Sil Lee
  • Soon Sung Lim
  • Sanghyun Lee
  • Kuk Hyun Shin
  • Yeong Shik Kim
Research Articles Articles

Abstract

The present study was carried out to clarify whether tectorigenin and tectoridin isolated from the rhizomes ofBelamcanda chinensis (Iridaceae) inhibit hepatic damage induced by carbon tetrachloride (CCI+4)-intoxication in rats by the experimental methodsin vitro andin vivo. Tectorigenin and tectoridin exhibited a significant decrease in serum transaminase activities elevated by hepatic damage induced by CCI4-intoxication in rats, as well as in a lipid peroxidation causing a significant decrease in malondialdehyde (MDA) production by thiobarbituric acid (TBA)-reactant assay. Both compounds also showed strong increase in the antioxidant enzymes such as hepatic cytosolic superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-px) activities in CCI4-intoxicated rats. These results suggested that tectorigenin and tectoridin isolated from the rhizomes ofB. chinensis possess not only the antioxidative, but also the hepatoprotective activities in CCI4-intoxicated rats.

Key words

Belamcanda chinensis Iridaceae Tectorigenin Tectoridin Carbon tetrachloride Antioxidant activity 

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Copyright information

© The Pharmaceutical Society of Korea 2004

Authors and Affiliations

  • Sang Hoon Jung
    • 1
    • 2
  • Yeon Sil Lee
    • 3
  • Soon Sung Lim
    • 4
  • Sanghyun Lee
    • 1
  • Kuk Hyun Shin
    • 1
    • 3
  • Yeong Shik Kim
    • 1
  1. 1.Natural Products Research Institute, College of PharmacySeoul National UniversitySeoulKorea
  2. 2.Natural Products Research CenterKorea Institute of Science and TechnologySeoulKorea
  3. 3.Seokwon Life Science Research InstitutePajuKorea
  4. 4.Silver Biotechnology Research CenterHallym UniversityChunchonKorea

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