Phenolic and furan type compounds isolated fromGastrodia elata and their anti-platelet effects

  • Mi Kyung Pyo
  • Jing Ling Jin
  • Yean Kyoung Koo
  • Hye Sook Yun-ChoiEmail author
Research Articles Articles


Nine phenolic (1–9) and two furan type (10,11) compounds, were isolated from the methan-olic extract of the tuber ofGastrodia elata Blume (Orchidaceae) in the course of continuing search for platelet anit-aggregating plant components. Compound1 was identified as 4,4′-dihy-droxybenzyl sulfone, a novel compound for the best of our knowledge. Compound10, 5-hydroxymethyl-2-furancarboxaldehyde, was isolated for the first time from this plant. Compound1 (IC50; 83 μM) was about four times more inhibitory to U46619 induced aggregation than ASA (IC50; 340 μM). Compound9, 4,4′-dihydroxy-dibenzylether, (IC50; 5 μM, 3 μM and 33uM, respectively) was 10–80 fold more potent than ASA (IC50; 420 μM, 53 μM and 340 μM respectively) to collagen, epinephrine and U46619 induced aggregation, although it is less active than ASA to AA induced aggregation.

Key words

Gastrodia elata 4,4-Dihydroxybenzyl sulfone 5-Hydroxymethyl-2-furancaboxal-dehyde 4,4-Dihydroxy-dibenzylether 


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Copyright information

© The Pharmaceutical Society of Korea 2004

Authors and Affiliations

  • Mi Kyung Pyo
    • 2
  • Jing Ling Jin
    • 3
  • Yean Kyoung Koo
    • 1
  • Hye Sook Yun-Choi
    • 1
    Email author
  1. 1.Natural Products Research InstituteSeoul National UniversitySeoulKorea
  2. 2.E.S. Life Science Research InstituteCheonanKorea
  3. 3.Institute of BioimmunologyYanbian University Collage of MedicineYanjiChina

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