Archives of Pharmacal Research

, Volume 22, Issue 5, pp 520–523 | Cite as

HIV integrase inhibitory activity ofAgastache rugosa

  • Hye Kyong Kim
  • Hyeong-Kyu Lee
  • Cha-Gyun Shin
  • Hoon Huh
Research Articles Natural Products

Abstract

We have been screening anti-HIV integrase compounds from Korean medicinal plants by using anin vitro assay system which is mainly composed of recombinant human immunodeficency virus type 1 integrase and radiolabeled oligonucleotides. From the above screening, the aqueous methanolic extract of the roots ofAgastache rugosa exhibited a significant activity. Bioactivity-guided chromatographic fractionation of the methanolic extract resulted in the isolation of rosmarinic acid. The structure of the compound was determined by spectroscopic data and by the comparison with the reported values. The IC50 of the rosmarinic acid was approximately 10 μ/ml against HIV integrase.

Key words

HIV integrase Agastache rugosa Labiatae Rosmarinic acid 

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Copyright information

© The Pharmaceutical Society of Korea 1999

Authors and Affiliations

  • Hye Kyong Kim
    • 1
  • Hyeong-Kyu Lee
    • 2
  • Cha-Gyun Shin
    • 3
  • Hoon Huh
    • 1
  1. 1.Research Institute of Pharmaceutical Sciences, College of PharmacySeoul National UniversitySeoulKorea
  2. 2.Korea Research Institute of Bioscience and BiotechnologyKISTTaejonKorea
  3. 3.Department of BiotechnologyChung-Ang UniversityAn-SungKorea

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