Hydrolysable tannins and related compound having cytotoxic activity from the fruits ofTerminalia chebula
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The cytotoxicity-directed fractionation of MeOH extract ofTerminalia chebula fruits led to the isolation of three hydrolyzed tannins and a related compound, gallic acid(I), 1,2,3,4,6-penta-O-galloyl-β- d -glucopyranose(II), chebulagic acid(III) and chebulinic acid(IV), as active principles. They were shown to exhibit moderate cytotoxicity against cultured human tumor cell lines including A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15in vitro.
Key wordsTerminalia chebula Gallic acid 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose Chebulagic acid Chebulinic acid Cytotoxicity Antitumor
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