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Archives of Pharmacal Research

, Volume 18, Issue 2, pp 118–120 | Cite as

Hydrolysable tannins and related compound having cytotoxic activity from the fruits ofTerminalia chebula

  • Seung-Ho Lee
  • Shi Yong Ryu
  • Sang Un Choi
  • Chong Ock Lee
  • Zaesung No
  • Seong-Kie Kim
  • Jong-Woong Ahn
Research Articles

Abstract

The cytotoxicity-directed fractionation of MeOH extract ofTerminalia chebula fruits led to the isolation of three hydrolyzed tannins and a related compound, gallic acid(I), 1,2,3,4,6-penta-O-galloyl-β- d -glucopyranose(II), chebulagic acid(III) and chebulinic acid(IV), as active principles. They were shown to exhibit moderate cytotoxicity against cultured human tumor cell lines including A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15in vitro.

Key words

Terminalia chebula Gallic acid 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose Chebulagic acid Chebulinic acid Cytotoxicity Antitumor 

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Copyright information

© The Pharmaceutical Society of Korea 1995

Authors and Affiliations

  • Seung-Ho Lee
    • 1
    • 2
  • Shi Yong Ryu
    • 1
    • 2
  • Sang Un Choi
    • 1
    • 2
  • Chong Ock Lee
    • 1
    • 2
  • Zaesung No
    • 1
    • 2
  • Seong-Kie Kim
    • 1
    • 2
  • Jong-Woong Ahn
    • 1
    • 2
  1. 1.Korea Research Institute of Chemical Technology (KRICT)Dae-jeonKorea
  2. 2.College of PharmacyYeungnam UniversityKyongsanKorea

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