Archives of Pharmacal Research

, Volume 22, Issue 4, pp 417–422

Two new lignans fromLindera obtusiloba blume

  • Hak Cheol Kwon
  • Sang Un Choi
  • Jung Ock Lee
  • Ki Hwan Bae
  • Ok Pyo Zee
  • Kang Ro Lee
Research Articles Natural Products

Abstract

Two new furanolignans (3, 5), together with three known lignans (1, 2, 4), were isolated from the stem ofLindera obtusiloba (Lauraceae). The structures of the compounds were determined as actifolin (1), pluviatilol (2), 5,6-dihydroxymatairesinol (3), (+)-syringaresinol (4), and (+)-9′-O-trans-feruloyl-5,5′-dimethoxylariciresinol (5) on the basis of physicochemical and spectroscopic evidences. Compounds1, 2, 3, and5 showed cytotoxicity against a small panel of human tumor cell lines with ED50 values of 3.40∼19.27 μg/ml.

Key words

Lindera obtusiloba Lauraceae Cytotoxicity Lignan Actifolin Pluviatilol 

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Copyright information

© The Pharmaceutical Society of Korea 1999

Authors and Affiliations

  • Hak Cheol Kwon
    • 3
  • Sang Un Choi
    • 1
  • Jung Ock Lee
    • 1
  • Ki Hwan Bae
    • 2
  • Ok Pyo Zee
    • 3
  • Kang Ro Lee
    • 3
  1. 1.Korea Research Institute of Chemical TechnologyDaejeonKorea
  2. 2.College of PharmacyChungnam National UniversityDaejeonKorea
  3. 3.Natural Products Laboratory, College of PharmacySung Kyun Kwan UniversitySuwonKorea

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