Advertisement

Archives of Pharmacal Research

, 28:1224 | Cite as

Cytotoxic constituents from the whole plant ofcorydalis pallida

  • Hyang Rim Kim
  • Hye -Young Min
  • Yeon Hee Jeong
  • Sang Kook Lee
  • Nam Sook Lee
  • Eun -Kyoung Seo
Article

Abstract

Here we report the cytotoxic activity of three known compounds isolated for the first time fromCorydalis pallida (Papaveraceae). An isoquinoline alkaloid, berberine, exhibited cytototoxic activity against two human cancer cell lines, HT-1080 (human fibrosarcoma) and SNU-638 (human stomach adenocarcinoma), with IC50 values of 3.2 and 3.4 μg/mL, respectively.N-trans-feruloyltyramine andN- trans-feruloylmethoxytyramine were also isolated from this plant but were inactive.

Key words

Corydalis pallida Papaveraceae Berberine N-trans-Feruloylmethoxytyramine N-trans-Feruloyltyramine Cytotoxicity 

References

  1. Blasko, G, Cordell, G. A., Bhamarapravati, S., Beecher, S., and Christopher, W. W., carbon-13 NMR assignments of berberine and sanguinarine.Heterocycles, 27, 911–16 (1988).CrossRefGoogle Scholar
  2. Cavin, A., Hostettmann, K., Dyatmyko, W., and Potterat, O., Antioxidant and lipophilic constituents ofTinospora crispa.Planta Med., 64, 393–396 (1998).PubMedCrossRefGoogle Scholar
  3. Chen, C.-Y., Chang, F.-R., Yen, H.-R, and Wu, Y.-C., Amides from stems ofAnnona cherimola.Phytochemistry, 49, 1443–1447 (1998).CrossRefGoogle Scholar
  4. Cutillo, F., D’Abrosca, B., DellaGreca, M., Di M. C., Golino, A., Previtera, L., and Zarrelli, A., Cinnamic acid amides fromChenopodium album: effects on seeds germination and plant growth.Phytochemistry, 64, 1381–1387 (2003).PubMedCrossRefGoogle Scholar
  5. Dostal, J., Man, S., Seckarova, P., Hulova, D., Necas, M., Potacek, M., Tousek, J., Dommisse, R., Dongen, W. V., and Marek, R., Berberine and coptisine free bases.J. Mol. Struct, 687, 135–142(2004).CrossRefGoogle Scholar
  6. Eun, J. S., Cho, H. J., Yang, J. H., Jeon, H., and Kim, Y. A., Cytotoxicity of reaction-precipitate from Coptidis Rhizoma and Glycyrrhizae Radix aqueous mixture.Saengyak Hakhoechi, 25, 356–62 (1994).Google Scholar
  7. Furuya, T., Ikuta, A., and Syono, K., Alkaoids from Callus tissue ofPapaver somniferum.Phytochemistry, 11, 3041–3044 (1972).CrossRefGoogle Scholar
  8. Ito, C., Itoigawa, M., Tokuda, H., Kuchide, M., Nishino, H., and Furukawa, H., Chemopreventive activity of isoquinoline alkaloids fromCorydalis plants.Planta Med., 67, 473–475 (2001).PubMedCrossRefGoogle Scholar
  9. Ju, H. S., Li, X. J., and Zhao, L., Scavenging effect of berbamine on active oxygen radicals in phorbol ester-stimulated human polymorphonuclear leukocytes.Biochem. Pharmacol., 39, 1673–1678 (1990).PubMedCrossRefGoogle Scholar
  10. Kametani, T., Ihara, M., and Honda, T., Two new alkaloids; kikemanine and the morphinandienone-type alkaloid, pallidine, fromCorydalis species.J. Chem. Soc. D: Chemical Communications, 22, 1301 (1969).CrossRefGoogle Scholar
  11. Kametani, T., Takemura, M., and lhara, M., (+)-Corytuberine fromCorydalis pallida var.tenuis. Phytochemistry, 15, 2017 (1976).CrossRefGoogle Scholar
  12. Kaneko, H. and Naruto, S., Constituents ofCorydalis species. VII. Constituents ofCorydalis pallida var.tenuis. Yakugaku Zasshi.,91, 101–108(1971).Google Scholar
  13. Kashiwabara, S., and Kawaguchi, Y., Berberine alkaloids as antibacterial agents.Jpn. Kokai Tokkyo Koho, 3 (1977).Google Scholar
  14. Kedzia, B., Alkiewicz, J., Holderna-Kedzia, E., Pic, S., and Nowacka, M., Antimicrobial properties of berberine and possibilities of its use in therapy.Herba Polonica, 38, 105–112 (1992).Google Scholar
  15. Kim, M., Shin, M. K., Ahn, D. G., and Lee, K. S. Chungyak daesajun vol. 6, Jungdam Publisher, Seoul, pp. 2420–2423 (1997).Google Scholar
  16. Kumazawa, Y., Itagaki, A., and Fukumoto, M., Activation of peritoneal macrophages by berberine-type alkaloids in terms of induction of cytostatic activity.Int. J. Immunopharmacol., 6, 587–592 (1984).PubMedCrossRefGoogle Scholar
  17. Lee, S. K., Cui., B., Mehta, R. R., Kinghorn, A. D., and Pezzuto, J. M., Cytostatic mechanism and antitumor potential of novel1H-cyclopenta[b]benzofuran lignans isolated formAglaia elliptica.Chemico-Biological Interac., 115, 215–228 (1998).CrossRefGoogle Scholar
  18. Ley, J. P., Krammer, G., Muche, S., Kindel, G., and Reiss, I., Use of ferulic acid amides as flavoring materials for foods and oral hygiene products.Eur. Pat. Appl., 12 (2003).Google Scholar
  19. Manske, R. H. F., The alkaloids of fumariaceous plants. XXV.Corydalis pallida Pers.Can. J. Res., 18, 80–83 (1940).Google Scholar
  20. McDevitt, J. T., Berberine alkaloids as a treatment for chronic, protozoally-induced diarrhea.PCT Int. Appl., 17 (1998).Google Scholar
  21. Polyakova, A. F., Rostotskii, B. K., and Dubinin, N. S., Isolation ofCorydalis pallida alkaloids.Tr. Alma-At. Med. Inst., 26, 456–457 (1970).Google Scholar
  22. Sarker, S. D., Bartholomew, B., and Nash, R. J., Alkaloids fromBalanites aegyptiaca.Fitoterapia, 71, 328–330 (2000).PubMedCrossRefGoogle Scholar
  23. Stekol’nikov, L. I., New alkaloids.Priroda, 5, 107 (1970).Google Scholar
  24. Tan, Y., Chen, W., Li, Y., Zhou, B., Chen, G., and Guo, S., Effects of Liandai tablet and its main active components on gastric cancer cell line MGC-803.Guangzhou Zhongyiyao Daxue Xuebao, 18, 67–70 (2001).Google Scholar
  25. Tanaka, H., Nakamura, T., Ichino, K., and Ito, K., A phenolic amide fromActinodaphne longifolia.Phytochemistry, 28, 2516–2517(1989).CrossRefGoogle Scholar
  26. Tomoike, H., Matsumoto, M., Aridzuka, T., and Sayama, K., Antioxidants from plants for therapeutic uses.Jpn. Kokai Tokkyo Koho, 6 (2000).Google Scholar
  27. Wong, W., Seow, W. K., O’Callaghan, J. W., and Thong, Y. H., Comparative effects of tetrandrine and berbamine on subcutaneous air pouch inflammation induced by interleukin- 1, tumour necrosis factor and platelet-activating factor.Agents and Actions, 36, 112–118 (1992).PubMedCrossRefGoogle Scholar
  28. Yokozawa, T., Tanaka, T., and Kimura, T., Examination of the nitric oxide production-suppressing component inTinospora tuberculata.Biol. Pharm. Bull., 24, 1153–1156 (2001).PubMedCrossRefGoogle Scholar

Copyright information

© The Pharmaceutical Society of Korea 2005

Authors and Affiliations

  • Hyang Rim Kim
    • 1
  • Hye -Young Min
    • 1
  • Yeon Hee Jeong
    • 1
  • Sang Kook Lee
    • 1
  • Nam Sook Lee
    • 2
  • Eun -Kyoung Seo
    • 1
  1. 1.College of PharmacyEwha Womans UniversitySeoulKorea
  2. 2.College of Natural SciencesEwha Womans UniversitySeoulKorea

Personalised recommendations