Archives of Pharmacal Research

, 28:1224 | Cite as

Cytotoxic constituents from the whole plant ofcorydalis pallida

  • Hyang Rim Kim
  • Hye -Young Min
  • Yeon Hee Jeong
  • Sang Kook Lee
  • Nam Sook Lee
  • Eun -Kyoung Seo


Here we report the cytotoxic activity of three known compounds isolated for the first time fromCorydalis pallida (Papaveraceae). An isoquinoline alkaloid, berberine, exhibited cytototoxic activity against two human cancer cell lines, HT-1080 (human fibrosarcoma) and SNU-638 (human stomach adenocarcinoma), with IC50 values of 3.2 and 3.4 μg/mL, respectively.N-trans-feruloyltyramine andN- trans-feruloylmethoxytyramine were also isolated from this plant but were inactive.

Key words

Corydalis pallida Papaveraceae Berberine N-trans-Feruloylmethoxytyramine N-trans-Feruloyltyramine Cytotoxicity 


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Copyright information

© The Pharmaceutical Society of Korea 2005

Authors and Affiliations

  • Hyang Rim Kim
    • 1
  • Hye -Young Min
    • 1
  • Yeon Hee Jeong
    • 1
  • Sang Kook Lee
    • 1
  • Nam Sook Lee
    • 2
  • Eun -Kyoung Seo
    • 1
  1. 1.College of PharmacyEwha Womans UniversitySeoulKorea
  2. 2.College of Natural SciencesEwha Womans UniversitySeoulKorea

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